76003-29-7, 1-Boc-3-Oxopiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 500 mL three-necked flask, 12.70 g (63.0 mmol, 1.0 eq.) of Compound 1 was dissolved in 280 mL of dimethylformamide and cooled to 0 C in an ice bath.1.73 g (73.0 mmol, 1.15 equivalents) of sodium hydride were added and stirred under ice cooling for 1 hour.Then 6.60 mL (69.0 mmol, 1.10 equivalents) of methyl bromoacetate was added via syringe.After further stirring for 20 minutes under ice cooling, the reaction solution was warmed to room temperature.After 18 hours, 10 mL of methanol, 10 mL of deionized water and 180 mL of a saturated sodium chloride solution were added to the reaction solution.The aqueous phase was extracted once with 250 mL and extracted three times with 140 mL of diethyl ether.The combined organic phases were dried with MgSO Subsequently, the residual dimethylformamide was removed under reduced pressure at a water temperature of 55 C over 2 hours to obtain 13.4 g of an orange liquid.Purification by flash chromatography using petroleum ether / ethyl acetate 4:1: petroleum ether / ethyl acetate 2:1 as eluent to afford white solid, yield: 14.16 g (82%, 52.0 mmol)., 76003-29-7
The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shaoxing University; Hu Chunqi; Li Xin; Shi Yaru; Du Wenting; Tong Jie; Su Wanting; Xia Weiqi; (20 pag.)CN108610332; (2018); A;,
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