With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.187669-60-9,1-(4-(Methylsulfonyl)phenyl)piperazine,as a common compound, the synthetic route is as follows.
Step 3: To a solution of 2-(6-bromopyridin-3-yl)-5-chloro-lH-berizimidazole (70mgs 0.227mmol) and l-[4-(meraylsulfonyl)phenyl]piperazine (54.5mgf 0.227mmol) in dry DMA (3mL) was added N,N-diisopropylethylamine (59mg, 0.454mmol). The mixture was heated to 110 C under argon for 16 hours. The mixture was filtered and was purified by reverse phase Prep HPLC using 30-60% C?CN/H2O/0.1%TFA as gradient to give 5-cMoro-2-(6-{4-(4- (methylsulfonyl)phenyl]piperazin-l-yl}pyridin-3-yl)-lH-benzimidazole as the TFA salt. LC-MS (M+H)= 468, 187669-60-9
187669-60-9 1-(4-(Methylsulfonyl)phenyl)piperazine 735904, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; SCHERING CORPORATION; SPERBECK, Donald, M.; DEVITA, Robert, J.; BALKOVEC, James, M.; GREENLEE, Mark, L.; WU, Zhicai; YU, Yang; VACHAL, Petr; ZHOU, Gang; WU, Heping; KUANG, Rongze; TING, Pauline; ASLANIAN, Robert; WO2012/64569; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics