With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.438049-91-3,(3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,438049-91-3
To a solution of 1 -bromo-4-fluoro-2-methoxybenzene (910 mg, 4.4 mmol) and 1 M KHMDS (18 ml_, 18 mmol) in 1 ,4-dioxane (9 mL) was added tert- butyl (3R,5R)- 3,5- dimethylpiperazine-1 -carboxylate (950 mg, 4.4 mmol). The reaction mixture was stirred at 100 C for 3 h. The solvent was removed and the residue was purified by column chromatography (petroleum ether/EtOAc = 20:1 ) to provide tert- butyl {3R,5R)- 4-(3-fluoro-5- methoxyphenyl)-3,5-dimethylpiperazine-1 – carboxylate. LC-MS (ESI): m/z 339.0 [M+H]+.
The synthetic route of 438049-91-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KEZAR LIFE SCIENCES; JOHNSON, Henry; (166 pag.)WO2019/178510; (2019); A1;,
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