With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142-64-3,Piperazine Dihydrochloride,as a common compound, the synthetic route is as follows.
Anhydrous piperazine 1 9.5 g (0.11 mol) and piperazinium dihydrochloride 2 31.8 g (0.2 mol) were dissolved in ethanol (80 mL), and the mixture was heated at 75 C for 3 h. To the solution, benzyl chloride 13.9 g (0.11 mol) was added dropwise. The reaction mixture was refluxed for another 2 h monitoring by TLC. The stirring mixture was cooled and then filtered. The filter cake was washed with ethanol and the filtrate was concentrated in vacuo, which was then washed with a solution of NaOH (6 M, pH > 12). The aqueous layer was extracted with CH2Cl2 at pH > 12. The organic layers were combined, dried over Na2SO4, and concentrated in vacuo. The crude product was purified by flash column chromatography on silica gel (1:3 MeOH/CH2Cl2) to give N-benzylpiperazine 3 18.4 g; yield 95 %. 1HNMR (500 MHz, CDCl3): 7.34-7.28 (m, 5H, Ph), 3.57 (s, 2H, OBn), 3.23 (s, 4H, piperazine-H), 2.77 (s, 4H, piperazine-H). MS (ESI): m/z = 176 (M+ +H). Spectroscopic data are according to the literature [19]., 142-64-3
The synthetic route of 142-64-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Hu, Xiao; Qiu, Qiong; Wang, Wen-Ling; Wang, Jin; Research on Chemical Intermediates; vol. 43; 1; (2017); p. 57 – 61;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics