373608-48-1, tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
373608-48-1, Bis(trimethylsilyl)amide lithium (1 M in THF, 10,3 mL, 10.3 mmol) was added to a stirred suspension of 2-(2-fluoro-4-methoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (0.679 g, 2.06 mmol) and 1-tert-butoxycarbonyl-4-(3-aminopropyl)piperazine (0.957 g, 3.93 mmol) in anhydrous THF (20 mL). After the addition was complete, the reaction was heated to reflux with stirring for 24 h. After that time the reaction was cooled to rt, diluted with saturated aqueous NH4CI (15 mL) and concentrated under reduced pressure. Saturated aqueous NaHC03 (SO mL) was added and the mixture was extracted with chloroform (4 x 30 mL). The combined organic layers were dried (MgSO4) and concentrated under reduced pressure. The product was purified by flash column chromatography (silica gel, 98:2 chloroform methanol) followed by recrystalization from chloroform/hexanes to give 5,7-dimethoxy-2-(4-methoxy-2-[3-(1-tert-butoxycarbonylpiperazin-4-yl)propylamino]phenyl)quinazolin-4(3H)-one (0.253 g, 22%) as a yellow solid:
The synthetic route of 373608-48-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zenith Epigenetics Corp.; Quinn, J.F.; Khlebnikov, V.; (124 pag.)CN105593224; (2016); A;,
Piperazine – Wikipedia
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