With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.
A solution of 2-methyl-5-fluoroquinazoline (100 mg; 0.616 MMOL ; 1EQ), 2- methylpiperazine (310 mg; 3.083 MMOL ; 5eq) and triethylamine (0.17 mL; 1.23 MMOL ; 2 eq) in dry DMF (2.5 mL) was heated at 120C for 5 h. The yellow solution was cooled and the solvent was evaporated in vacuo. The crude material was purified on SPE cartridge (Si; 2 g) eluting with a gradient from 100% dichloromethane to 85% DICHLOROMETHANE : 1% NH40H 2M sol in methanol to afford the title compound (D15) (85 mg; yield 57%). MS; (ES) m/z: 243.3 [MH+]. CAHSN4 requires 242.32. ‘H NMR (300MHZ, CDCI3) 8 : 9.48 (s, 1H), 7.81 (t, 1H), 7.48 (d, 1H), 7.10 (d, 1H), 3.03 (m, 1H), 3.23-2. 98-2.76-2. 41 (m, 6H), 2.72 (s, 3H) 1.01 (d, 3H).
109-07-9, The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/46124; (2004); A1;,
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