With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.
A solution of 2.2 mMol 6-(6-chloropyrimidin-4-yloxy)-naphthalene-1-carbonyl chloride (Step19.3) in 15 ml CH2CI2 is added to a stirred solution of 410 mg (2.0 mMol) 4-(4-methyl- piperazin-1-ylmethyl)-phenylamine and 680 mul (4.0 mMol) diisopropylethylamine in 15 mlCH2CI2. After 30 min, the reaction mixture is poured into a mixture of NaHCO3 and CH2CI2.The aq. phase is separated off and extracted with CH2CI2. The combined organic layers are washed with water and brine, dried (Na2SO4) and concentrated to give the crude product which is purified by column chromatography (SiO2; CH2CI2/Et0H/NH395:4.5:0.5) to afford the title compound as a yellow powder., 70261-82-4
70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/104538; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics