With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.
Step 3.Synthesis of 4-(4-ethylpiperazinyl)benzeneisothiocyanate To 4-(4-ethylpiperazinyl)phenylamine in acetone at 0 C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq).The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water.The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 4-(4-ethylpiperazinyl)benzeneisothiocyanate. MS: MH+=247.
115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.
Reference£º
Patent; Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard; US2004/122237; (2004); A1;,
Piperazine – Wikipedia
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