115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a 0.342 g of 4-(4-ethylpiperazine-1-yl)phenylamine (4d;0.00167 mol) in a dry round bottom flask was added 10 mL 98%ethanol. Then 0.265 g of ethyl 2,4-dioxo-6-methylcyclohexanecarboxylate(E164; previously synthesized in our lab)23 was added. The reactionmixture was refluxed for about 6 h and a total of 5 mL additionalethanol was added. The reaction was monitored by thin layer chromatography(dichloromethane: methanol 85/15). After 6 h, the heatwas turned off and reaction continued to stir at room temperatureovernight. After reaction was completed, the reaction was adsorbed ona silica gel and purified by automated flash chromatography (dichloromethane:methanol 75/25) to yield a yellow semi-solid (54)(0.154 g, 30%).1H NMR (300 MHz, d-CDCl3): delta (ppm) 1.099-1.176 (t,3H), 1.276-1.355 (t, 3H), 1.951 (d, 3H), 2.392-2.547 (q, 2H),2.498-2.641 (t, 4H), 3.211-3.244 (t, 4H), 4.239-4.287 (q, 2H), 5.403(s, 1H), 6.873-6.903 (d, 2H), 7.039-7.069 (d, 2H). HRMS (ESI): m/z,Calcd. for C22H31N3O3 [M+H]+: 386.2433, found 386.2564.
115619-01-7, As the paragraph descriping shows that 115619-01-7 is playing an increasingly important role.
Reference£º
Article; Ghoneim, Ola M.; Bill, Ashley; Dhuguru, Jyothi; Szollosi, Doreen E.; Edafiogho, Ivan O.; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 3890 – 3898;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics