With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: Compound 9a-9j were synthesized according to the procedure previously described.8 The above mixture (containing 8) was added a solution of amines (0.56 mmol) in dichloromethane (2 mL) in an ice bath. The reaction mixture was stirred overnight at room temperature, then added dropwise with saturated sodium bicarbonate solution in an ice bath, and the solution was extracted with dichloromethane (20 mL*3). The combined organic layer was dried over anhydrous NaSO4, and then concentrated to afford the crude product, which was further purified using chromatography on silica gel ( Petroleum ether / EtOAc) to obtain the products 9a-9j., 30459-17-7
The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Shu; Li, Gongming; Yang, Xiaohong; Meng, Qian; Yuan, Shuo; He, Yun; Sun, Dequn; Bioorganic and Medicinal Chemistry Letters; vol. 28; 13; (2018); p. 2275 – 2278;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics