With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.
17.6 g of N- (4-aminophenyl) -N, 4-dimethyl-1-piperazineacetamide was addedMethyl N-acetyl-3- [methoxy (phenyl) methylene] -2-oxoindoline-6-carboxylate19g was added to DMF15 mL and 75 mL of methanol,Reflux reaction 1.5h or more.The reaction solution was added with 9.4 g of N-methylpiperazine,Reaction 1h,Cooling,Filtration to 5 C.Nidanibu products25.1g.250 ml of nidadibugar methanol was recrystallized,The purity of purified nidadipine was 99.58%
262368-30-9, 262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Ruiyang Pharmaceutical Co., Ltd.; Miao Dezu; Hu Qingwen; Cong Chao; Wang Hongguang; Yu Zhibo; (9 pag.)CN106748960; (2017); A;,
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