21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
INTERMEDIATE 81fert-ButvK^-l-(2-rr35l.5i?V3.5-dimethvbiperazin-l-yll-7-fluoro-8-methylquinolin-3- yl } ethylcarbamateTo a solution of Intermediate 27 (500 mg, 1.48 mmol) in NMP (6 mL) were added (25′,6i?)-2,6-drmethylpiperazine (340 mg, 3.00 mmol) and DIPEA (1.3 mL) and the resulting solution was heated at 14O0C for 16 h. The reaction mixture was taken up in EtOAc (150 mL) and washed with water (2 x 50 mL) and brine (50 mL). The organic phase was separated, dried (MgSO4), filtered and the solvent removed in vacuo. Purification by column chromatography (SiO2, 0-5percent MeOH in EtOAc) gave the title compound (530 mg, 86percent) as a beige solid. deltaH (CDCl3) 7.90 (IH, s), 7.49 (IH, dd, J 8.87, 6.12 Hz), 7.12 (IH, t, .78.98 Hz)5 5.04 (2H, d, J38.75 Hz), 3.65 (IH, d, J 12.33 Hz), 3.43 (IH, d, J 12.40 Hz), 3.26 (IH, s), 3.14-3.09 (IH, m), 2.79 (IH5 1, J 11.35 Hz)5 2.60 (3H, d, J2.40 Hz)5 2.43 (IH51, J 11.28 Hz)5 1.48-1.42 (13H5 m), 1.15 (6H, dd5 J 14.95, 6.35 Hz).
21655-48-1, As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.
Reference£º
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACDONALD, Jonathan, David; MATTEUCCI, Mizio; NASH, David, John; OWENS, Andrew, Pate; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; SHARPE, Andrew; WO2010/100405; (2010); A1;,
Piperazine – Wikipedia
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