Simple exploration of 4318-42-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.,4318-42-7

Step B/lntermediate B62: 1-[2-fluoro-5-(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine; To 5-bromo-4-fluoro-2-nitrophenyl methyl ether (4.0 g, 16.0 mmol) in dioxane (150 ml.) was added 1-(1-methylethyl)piperazine (4.1 g, 32.0 mmol), XANTPHOS (0.9 g, 1.6 mmol), and Cs2CO3 (10.4 g, 32.0 mmol). The mixture was bubbled with N2 for 15 min prior to the addition of Pd2(dba)3 (0.7 g, 0.8 mmol). The reaction was stirred at 100 0C for 18 h. Ethyl acetate (100 ml.) was used to dilute the reaction mixture, followed by the addition of water (80 ml_). After partitioning, extraction with Ethyl acetate (2 x 75 ml_), drying (Na2SO4), filtration and concentration, silica gel chromatography afforded 1-[2-fluoro-5-(methyloxy)-4-nitrophenyl]-4-(1- methylethyl)piperazine as a yellow solid (3.3 g, 70percent yield). 1 H NMR (400 MHz,DMSO-de) delta ppm 0.98 (d, J=6.6 Hz, 6 H), 2.54 – 2.61 (m, 4 H), 2.68 (dt, J=13.2, 6.6 Hz, 1 H), 3.24 – 3.31 (m, 4 H), 3.91 (s, 3 H), 6.64 (d, J=I .1 Hz, 1 H), 7.82 (d, J=13.6 Hz, 1 H).

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/20990; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics