With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235865-77-6,2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid,as a common compound, the synthetic route is as follows.
In a 100-mL three necked round bottom flask equipped with magnetic stirrer, thermometer, condenser, charged 15 mL of 2-[(1H-Pyrrolo[2,3-b]pyridine-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid in THF (assay: 1 g, 1.75 mmol), heated up to 50-55C and 0.4 mL (5.25 mmol) trifluoroacetic acid in THF (2 mL) was added. The reaction mixture was stirred for 30 min at 50-55C and n-heptane (25 mL) was added dropwise at this temperature. The reaction mixture was cooled to 0-5C, stirred for 30 min and filtered. The wet cake was washed with n-heptane (2.5 mL) and dried under vacuum at 40- 45C overnight to obtain desired compound (assay: 0.85 g, 85%, TFA: 14.8%)., 1235865-77-6
As the paragraph descriping shows that 1235865-77-6 is playing an increasingly important role.
Reference£º
Patent; ASSIA CHEMICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; POTARINE JUHASZ, Zsuzsa; STRUBA, Szabolcs; NEMETHNE RACZ, Csilla; TOTH, Zoltan Gabor; SZILAGYI, Andrea; KERTI-FERENCZI, Renata; MOLNAR, Sandor Janos; PASZTOR-DEBRECZENI, Nora; HAJKO, Janos; (100 pag.)WO2017/156398; (2017); A1;,
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