142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(1) Put the solvent ethanol into the reactor, add piperazine, and stir to dissolve all the piperazine. Hydrochloric acid is added dropwise under the condition of 20 C to make the reaction solution PH = 2 as an end point; after reacting for 1 hour and cooling to 20 C,Pipette rejection by centrifugation to give piperazine dihydrochloride, the mother liquor can continue to be concentrated to give piperazine dihydrochloride;(2) The ethanol into the reaction vessel was added with stirring 42g piperazine dihydrochloride and 21g of piperazine,Reaction at 68 C for 3 hours;(3) cooling to 45 C dropwise cinnamyl chloride 36g, after the dropwise addition was warmed to 60 incubated for 4 hours,And then cooled to 10 C, centrifuged, the solid filter cake was recovered to give piperazine dihydrochloride recycling, the mother liquor drawn into the distillation reactor;(4) heat distillation mother liquor recovery solvent,The solvent is no longer out when adding purified water,Dropping lye to adjust PH to 12,The mixture was extracted with chloroform twice, the organic phases were combined and the organic phase was washed twice with water. The organic phase was separated and dried over anhydrous sodium sulfate overnight. The chloroform was then recovered by distillation and the product was still hot while still in the still pot to give cinnamylpiperazine., 142-64-3
As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.
Reference£º
Patent; Zhengzhou Ruikang Pharmaceutical Co., Ltd.; Zhang Jie; Zhang Guoyong; Li Mingxuan; Liu Yuanyuan; (6 pag.)CN106366051; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics