With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.393781-70-9,(R)-1-Boc-2-Ethylpiperazine,as a common compound, the synthetic route is as follows.
Step A: To a solution of (R)-tert-butyl 2-ethylpiperazine-l-carboxylate (0.208 g, 0.971 mmol, Eq: 1.00) and triethylamine (0.135 ml, 0.971 mmol, Eq: 1.00) in DMF (2ml) was added methyl 2,6- dichloronicotinate (0.200 g, 0.971 mmol, Eq: 1.00) and the reaction mixture stirred at 30C for 4.5 hrs. The reaction mixture was diluted with EtOAc and washed with water and brine, the organic phase was dried over Na2S04 and the solvent evaporated. The crude was purified by column chromatography (Si02, EtOAc/Heptane, 1/4) to give 160 mg (43%) of tert-butyl (2R)-4- (6-chloro-5-methoxycarbonyl-2-pyridyl)-2-ethyl-piperazine-l-carboxylate as a white solid. MS (m/e): 384.2 (M+H+)., 393781-70-9
As the paragraph descriping shows that 393781-70-9 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GREEN, Luke; PINARD, Emmanuel; RATNI, Hasane; WILLIAMSON, Patrick; (95 pag.)WO2015/197503; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics