With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-27-2,1-Methylpiperazin-2-one hydrochloride,as a common compound, the synthetic route is as follows.
Preparation of ethyl 2-(4-methyl-3-oxopiperazin-1-yl)-2-phenylacetate (I50) DIPEA (0.52 ml, 2.96 mmol) and 1-methylpiperazin-2-one hydrochloride (0.22 g, 1.48 mmol) were sequentially added to a solution of ethyl 2-bromo-2-phenylacetate (0.22 ml, 1.23 mmol) in acetonitrile (4 ml). The reaction was stirred at room temperature for 1.5 hours. DIPEA (0.13 ml, 0.74 mmol) was added again and the reaction was stirred at room temperature overnight. The solvent was evaporated and the crude was purified by flash chromatography (DCM/Acetone=9/1) to obtain ethyl 2-(4-methyl-3-oxopiperazin-1-yl)-2-phenylacetate (256 mg, 75% yield) as a yellow oil. 1H NMR (300 MHz, DMSO-d6) ppm 6.91-7.66 (m, 5H), 4.28 (s, 1H), 3.99-4.22 (m, 2H), 3.23 (t, 2H), 3.00 (s, 2H), 2.80 (s, 3H), 2.61-2.71 (m, 2H), 1.14 (t, 3H).
109384-27-2, The synthetic route of 109384-27-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chiesi Farmaceutici S.p.A.; AMARI, Gabriele; Pesenti, Cristina; Bossolo, Stefano; US2013/172302; (2013); A1;,
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