55121-99-8, (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,55121-99-8
mCPBA (<77% pure) (77 mg, assumed 0.342 mmol) in DCM (0.5 mL) was added to a stirred solution of 6- (2,6- dichlorophenyl ) -2 - (methylthio) pyrido [4 , 3 -d] pyrimidin-5 ( 6H) one (100 mg, 0.296 mmol) in toluene (3.0 mL) at RT under nitrogen. After 30 min, DIPEA (0.155 mL, 0.887 mmol) and (4 -aminophenyl ) (4 -methylpiperazin- 1 -yl ) methanone (64.8 mg, 0.296 mmol) [commercially available] were added,successively and the temperature was increased to 60 C. After 16 h, the reaction mixture was cooled and loaded directly onto a KP-NH column and purified by flash chromatography (0-100%, EtOAc in cyclohexane) . The resultant material required re-purification by flash chromatography on a KP-Sil column (0-10%, MeOH in EtOAc) . The resultant material required re-purification by preparative HPLC . The pure fractions were concentrated and the resultant material was freeze-dried to give the title compound (10.2 mg, 7%) as a white solid. LCMS (Method A): RT = 0.79 min, m/z = 509, 511 [M+H]+. 1U NMR (500 MHz, methanol -d4 ) : delta 9.28 (s, 1H) , 7.98 (d, 2H) , 7.66-7.62 (m, 2H) , 7.56-7.51 (m, 2H) , 7.48-7.43 (m, 2H) , 6.69 (d, 1H) , 3.68 (br s, 4H) , 2.49 (br s, 4H) , 2.34 (s, 3H) .
55121-99-8 (4-Aminophenyl)(4-methylpiperazin-1-yl)methanone 231408, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; O’DOWD, Colin Roderick; ROUNTREE, James Samuel Shane; BURKAMP, Frank; WILKINSON, Andrew John; WO2014/167347; (2014); A1;,
Piperazine – Wikipedia
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