With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5308-25-8,1-Ethylpiperazine,as a common compound, the synthetic route is as follows.,5308-25-8
a) Ethyl 2-(4-ethylpiperazin-l-yl)acetateTo a solution of 1 -ethylpiperazine (1 g, 8.771 mmol, 1.0 eq) in DMF were added K2C03 (3 g, 21.927 mmol, 2.5 eq.) and ethyl 2-bromoacetate (2.19 g, 13.156 mmol, 1.5 eq.). The mixture was stirred at RT for 16 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 76.4 % yield (1.3g).
As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.
Reference£º
Patent; ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu; WO2013/53983; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics