216144-45-5, 4-(4-Methylpiperazin-1-yl)benzylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The solution of compound 5 (150 mg, 0.58 mmol), 4-(4-Methylpiperazino)benzylamine (118 mg, 0.58 mmol) and DIPEA (0.15 ml, 0.86 mmol) DMSO (3.5 mL) was stirred at 105 C. for 2 hours. TLC was checked and the starting material was consumed. The reaction mixture was added to half-saturated ammonium chloride in water (80 mL) and stirred for 30 min, then cooled with ice bath. The solids were collected by filtration, washed by water. The crude product was purified by column chromatography (0-10% MeOH in DCM) to give the product compound 29 as yellow solids. (98 mg, 39% yield). 1H NMR (400 MHz, DMSO-d6) delta 12.10 (br, 1H), 10.67 (s, 1H), 8.34 (s, 1H), 8.28 (s, 1H), 7.20 (d, J=8.8 Hz, 2H), 6.90 (d, J=8.8 Hz, 2H), 5.69 (s, 1H), 4.67 (d, J=5.6 Hz, 2H), 3.10 (m, 4H), 2.43 (m, 4H), 2.21 (s, 3H), 1.98 (m, 1H), 0.98 (m, 2H), 0.79 (m, 2H); ESI-MS: calcd for (C23H27N9) 429, found 452 (MNa+).
216144-45-5, 216144-45-5 4-(4-Methylpiperazin-1-yl)benzylamine 2776493, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346450; (2018); A1;,
Piperazine – Wikipedia
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