With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.,109-07-9
General procedure: 2-Substituted piperazine or 2,6-Disubstitutedpiperazine (5.0 mmol) was dissolved in dry dichloromethane(100 mL) and cooled to 0 C. A solution of the appropriate acylatingagent (5.0 mmol) in dichloromethane (20 mL) was added dropwisein 30 min, and then pyridine (7.5 mmol). The reaction mixture waskept into an ice-water bath with stirring 12 h and left at roomtemperature until TLC showed that all the starting material hadreacted. The reaction mixture was evaporated to dryness to obtainthe corresponding monoacyl derivative. Column chromatographygave the pure compound in high yield.1-tert-Butoxycarbonyl-3-methylpiperazine (16) [21]. Theproduct was obtained as a syrup and purified by column chromatographyusing dichloromethane-methanol (15:1) as eluent(750 mg, 75% yield). MS (CI): m/z 201 (20%) [M+H]+. 1H NMR(500 MHz, DMSO-d6) delta 3.75-3.71 (m, 2H), 2.85-2.82 (m, 1H),2.75-2.69 (m, 1H), 2.60-2.54 (m, 3H), 2.39-2.34 (m, 1H), 1.41 (s,9H), 0.96 (d, J 6.3 Hz, 3H). 13C NMR (125 MHz, DMSO-d6) delta 154.5,79.3, 51.2, 50.5, 45.5, 44.4, 28.6, 19,3. HRMS (m/z): calcd forC10H20N2O2 200.1528 [M]+.; found 200.1525.
The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Mazzotta, Sarah; Marrugal-Lorenzo, Jose Antonio; Vega-Holm, Margarita; Serna-Gallego, Ana; Alvarez-Vidal, Jaime; Berastegui-Cabrera, Judith; Perez del Palacio, Jose; Diaz, Caridad; Aiello, Francesca; Pachon, Jeronimo; Iglesias-Guerra, Fernando; Vega-Perez, Jose Manuel; Sanchez-Cespedes, Javier; European Journal of Medicinal Chemistry; vol. 185; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics