With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76003-29-7,1-Boc-3-Oxopiperazine,as a common compound, the synthetic route is as follows.
A suspension of />-iodo-aniline (918mg, 4.8mmol), 3-oxo-piperazine-l-carboxylic acid tert-butyl ester (960mg, 4.2mmol) (7R,2R)-cyclohexane-l,2-diamine (0.05mL, 0.42mmol), copper (I) iodide (14.9mg,0.0042mmol) and K2CO3 (1.19g, 2.04mmol) in dioxane (4mL), is purged with nitrogen for 5 min in a reaction tube. The tube is sealed and the reaction mixture is heated at 1190C for 15 hours. After cooling to room temperature, the reaction mixture is filtered through a silica cartridge washing with ethyl acetate (4OmL). The filtrate is concentrated in vacuo to afford the title compound as a brown liquid (1.06g, 87%). LCMS: Rt 0.88min (91%)., 76003-29-7
The synthetic route of 76003-29-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
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