With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.438049-91-3,(3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.,438049-91-3
A mixture of (3S,5R)-tert-butyl 3,5-dimethylpiperazine-l-carboxylate (2.14g, 10.0 mmol), 3-bromopropan-l-ol (2.76 g, 20 mmol) and K2C03(2.76 g, 20 mmol) in DMF (5.0 mL) was heated to 90C for 2 h in a microwave. The reaction mixture was poured into water (30 mL) and extracted with EtOAc. The organic phase was separated, dried and concentrated. The residue was purified by chromatography (DCM:MeOH=30: 1) to provide (3R,5S)-tert-butyl 4-(3- hydroxypropyl)-3,5-dimethylpiperazine-l-carboxylate as a yellow liquid (2.14g, 50%).
438049-91-3 (3R,5R)-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate 51670829, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth Albert; VERNER, Erik; (122 pag.)WO2016/191172; (2016); A1;,
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