59702-07-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
To a solution of 4-(3-(4-cyanophenyl)imidazo[l,2-a]pyridin-6-yl)benzoic acid (70 mg, 0.206 mmol) in DMF (1.0 mL) were added HATU (1 17 mg, 0.309 mmol), N-methyl morpholine (90 iL, 0.824 mmol) and l-methylpiperazin-2-one (37 mg, 0.247 mmol). The reaction mixture was stirred at room temperature under inert atmosphere for 18 h, then it was diluted with water (15 mL) and extracted with EtOAc (3×30 mL). The combined organic layer was dried over Na2S04 and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluent CHCl3 MeOH 96:4) to afford 4-(6-(4-(4-methyl-3- oxopiperazine-l-carbonyl)phenyl)imidazo[l,2-a]pyridin-3-yl)benzonitrile (64 mg, 57percent, AUC HPLC 98percent) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.76 (bs, 1H), 7.97-7.89 (m, 4H), 7.88 (s, 1H), 7.84-7.78 (m, 2H), 7.77 (d, J= 1.2 Hz, 2H), 7.64-7.57 (m, 2H), 4.40- 4.10 (m, 2H), 4.10-3.60 (m, 2H), 3.57-3.42 (m, 2H), 3.01 (s, 3H); 13C NMR (100 MHz, CD3OD): delta 171.72, 147.44, 140.53, 135.51, 134.81 , 134.72, 134.38, 129.42, 129.27, 128.56, 128.52, 127.79, 126.58, 122.93, 119.50, 1 18.47, 112.70, 34.68; MS (ESI) m/z 436 [C26H21N502 + H] +.
The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
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