With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
59702-07-7, [0808] To a solution of (8-((5-cyano-4-((2-methoxyethyl)amino )pyridin-2-yl)carbamoyl)-2-( dimethoxymethyl)-5,6, 7,8-tetrahydro-1 ,8-naphthyridin-3-yl)methyl methanesulfonate(intermediate 170, 368 mg, 0.657 mmol) in DCM(2.7 ml) at room temperature was added NEt3 (0.319 ml,2.301 mmol) followed by 1-methylpiperazin-2-one (120 mg,1.052 mmol). The reaction mixture was stirred at room temperaturefor 2 hand partitioned between DCM and water. Thewater layer was extracted multiple times with DCM, thecombined organic layers were dried using Na2S04 , filteredand evaporated. The crude product was purified by silica gelcolunm chromatography using a gradient ofMeOH (0-3percent) inDCM to yield the title compound as a white solid. (UPLC-MS3) tR 0.87 min; ESI-MS 553.3 [M+Ht. 1H NMR (600 MHz,CDCI3 ) ll13.75 (s, lH), 8.20 (s, lH), 7.64 (br s, lH), 7.58 (s,lH), 5.56 (s, lH), 5.23 (d, lH), 4.06-4.01 (m, 2H), 3.70 (br s,2H), 3.63 (t, 2H), 3.50-3.42 (m, 8H), 3.40 (s, 3H), 3.31 (br s,2H), 3.14 (br s, 2H), 2.96 (br s, 3H), 2.87-2.80 (m, 2H), 2.71(br s, 2H), 2.03-1.96 (m, 2H).
The synthetic route of 59702-07-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Novartis AG; Buschmann, Nicole; Fairhurst, Robin Alec; Furet, Pascal; Knoepfel, Thomas; Leblanc, Catherine; Liao, Lv; Mah, Robert; Nimsgern, Pierre; Ripoche, Sebastien; Xiong, Jing; Han, Bo; Wang, Can; Zhao, Xianglin; US2015/119385; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics