192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 26; 4-{2-[3-(2-Methylsulfanyl-pyrimidin-4-yl)- lH-pyrazolo[3,4-d]pyrimidin-6-ylamino]- ethyl}-piperazine-l-carboxylic acid tert-butyl ester; To a solution of 6-chloro-3-(2-methylsulfanyl-pyrimidin-4-yl)- lH-pyrazolo[3,4- d]pyrimidine (from Example 7 supra) (500 mg, 1.79 mmol) in 2-propanol (40 mL) was added tert-butyl 4-(2-aminoethyl)piperazine- l-carboxylate (613 mg, 1.97 mmol) followed by triethylamine (200 mg, 1.98 mmol). The reaction mixture was stirred at reflux for 15 hours and the solvent was then removed under reduced pressure. The residue was extracted with dichloromethane (3 x 30 mL), washed with water (5 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to afford 4-{2-[3-(2-methylsulfanyl-pyrimidin-4-yl)- lH-pyrazolo[3,4- d]pyrimidin-6-ylamino] -ethyl }-piperazine- l-carboxylic acid tert-butyl ester. (Yield 600 mg, crude). LC-MS: [M+H]+ 472.
192130-34-0, 192130-34-0 tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate 1514400, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; LIU, Wenjian; LUK, Kin-Chun Thomas; ZHANG, Xiaohu; WO2012/98068; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics