With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-81-3,1-Methyl-4-(4-nitrobenzyl)piperazine,as a common compound, the synthetic route is as follows.
70261-81-3, To the 500 mL single neck flask was added 8.5 g (36.2 mmol) of crude I-a,FeO (OH) / C catalyst 2.0 g and 95% ethanol 100 mL,Heating reflux,A mixture of 25 mL of hydrazine hydrate and 20 mL of 95% ethanol was slowly added dropwise,TLC detects the disappearance of the starting material (methanol: chloroform = 1:15).The filter cake was washed twice with hot ethanol (30 mL x 2)The solvent was evaporated under reduced pressure to give a white solid,And dried in vacuo to give 6.7 g of (I-b) in a yield of 90.3%.Products without further purification, directly into the next step.
70261-81-3 1-Methyl-4-(4-nitrobenzyl)piperazine 677795, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; China Pharmaceutical University; Lu Shuai; Wang Yue; Zhi Yanle; Yao Chao; Lu Tao; Li Baoquan; Chen Puzhou; Bao Jiyin; (27 pag.)CN107245073; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics