75336-86-6, (R)-2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a 250 mL flask containing 100 mL toluene was added 2.45 g sodium t-butoxide (25.5 mmol, 1.5 equiv), 191 mg palladium acetate (0.85 mmol, 0.05 equiv) and 517 mg tri-/?-tolylphosphine (1.7 mmol, 0.1 equiv) under N:*. After stirring for 20 mm., 3.Og 1 -bromo-4-fluorobenzene (17.0 mmol, 1.0 equiv) and 1.71 g (/?)-2-methylpiperazine (17.0 mmol, 1.0 equiv) were added to the solution. The resulting mixture was placed into a preheated 110 0C bath. After stirring for 7 h, the mixture was cooled to room temperature and stirred overnight. The mixture was filtered though a plug of celite. The celite plug was washed with 2 x CH2Cl2. The organics were dried (MgSO4) and concentrated under reduced pressure. Flash chromatography of the residue (SiO2, 2percent MeOH/CH2Cl2 to 2percent MeOH/CH2Cl2 with 1percent NH4OH) gave the product as a light-browiti oil., 75336-86-6
75336-86-6 (R)-2-Methylpiperazine 7330434, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; AMGEN INC.; WO2007/70506; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics