169447-70-5, (S)-tert-Butyl 2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Methyl chloroformate (230 1iL, 3 mmol) was slowly added at 0C to a solution of tert-butyl (25)-2-methylpiperazine-i-carboxylate (300 mg, 1.5 mmol) and triethylamine (835 1iL, 6 mmol) in methylene chloride (6 mL). After stirring at r.t. for 1 h, reaction mixture wascarefully quenched by addition of water and the desired product was extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and solvent was evaporated under reduced pressure. Cmde material was purified by Biotage IsoleraTM to give (5)-i -tert-butyl 4-methyl 2-methylpiperazine- 1 ,4-dicarboxylate (378 mg, 97%). LCMS calculated for C7H15N202 (M+H-Boc) m/z = 159.1; found: 159.1., 169447-70-5
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Reference£º
Patent; INCYTE CORPORATION; VECHORKIN, Oleg; LI, Yun-Long; SOKOLSKY, Alexander; WANG, Anlai; ZHU, Wenyu; ZHUO, Jincong; (185 pag.)WO2017/59251; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics