Month: March 2021

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, belongs to piperazines compound. In a document, author is Vinarov, Zahari, introduce the new discover, Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine.

Solubilization of itraconazole by surfactants and phospholipid-surfactant mixtures: interplay of amphiphile structure, pH and electrostatic interactions

Although surfactants are frequently used in enabling formulations of poorly water-soluble drugs, the link between their structure and drug solubilization capacity is still unclear. We studied the solubilization of the brick-dust molecule itraconazole by 16 surfactants and 3 phospholipid:surfactant mixtures. NMR spectroscopy was used to study in more details the drug-surfactant interactions. Very high solubility of itraconazole (up to 3.6 g/L) was measured in anionic surfactant micelles at pH = 3, due to electrostatic attraction between the oppositely charged (at this pH) drug and surfactant molecules. H-1 NMR spectroscopy showed that itraconazole is ionized at two sites (2+ charge) at these conditions: in the phenoxy-linked piperazine nitrogen and in the dioxolane-linked triazole ring. The increase of amphiphile hydrophobic chain length had a markedly different effect, depending on the amphiphile type: the solubilization capacity of single-chain surfactants increased, whereas a decrease was observed for double-chained surfactants (phosphatidylglycerols). The excellent correlation between the chain melting temperatures of phosphatidylglycerols and itraconazole solubilization illustrated the importance of hydrophobic chain mobility. This study provides rules for selection of itraconazole solubilizers among classical single-chain surfactants and phospholipids. The basic physics underpinning the described effects suggests that these rules should be transferrable to other brick-dust molecules.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 130307-08-3. Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2, belongs to piperazines compound, is a common compound. In a patnet, author is Kurutos, Atanas, once mentioned the new application about 109-01-3, Safety of 1-Methylpiperazine.

Near-infrared pH responsive heptamethine cyanine platforms: Modulating the proton acceptor

In this report, we wish to present the rational design, synthesis, and study of optical characteristics of near-infrared (NIR) molecular probes emitting over 800 nm. The title pH sensing platforms consist of a piperazine moiety serving as a hydronium ion receptor, coupled with a rigidified symmetric heptamethine backbone. The spectrally fine-tuned response of the fluorophores was studied in both organic solvents and aqueous buffer solutions, employing combined UV-Vis and steady state fluorimetric techniques. In parallel, computational approach and optical spectroscopy were employed aiming to ascribe the origin of spectral behavior of the amino-substituted heptamethines. Herein, we also investigated the halochromic effect of the differently substituted piperazines on the spectral properties of the NIR cyanine dyes. Under acidic conditions, the protonation of the piperazine moiety promoted a gradual bathochromic shift in the absorption spectra. The Delta lambda between the neutral and the protonated forms are indirectly related to the modifications applied to the proton acceptor. The calculated pK(a) values (5.13-7.06) were found to be dependent on the dye chemical structure. A good linear correlation was established between the pK(a) of the newly synthesized dyes and that of the reported piperazine moieties. This aspect allows the future expansion of the current facile strategy since sensing chromophores with predicted pH response could readily be designed based on pK(a) databases for substituted piperazine derivatives. A detailed literature study along with NMR and computational methods were found to be in agreement with our assumption, that both nitrogen atoms of the 1,4-disubstituted amine are involved in the sensing process. The covered pK(a) range allows us to recommend the title fluorophores as promising potential candidates for qualitative analysis of biological samples. A cytotoxicity study by the MTT assay showed that the NIR dyes are safe and applicable for bioanalytical purposes at dye concentrations up to 10 mu M. Fluorescence imaging and cellular applications, including staining and visualization of HeLa cervical cancer cells was successfully demonstrated.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Noorbasha, Khaleel, once mentioned the application of 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2, molecular weight is 255.1542, MDL number is MFCD09029689, category is piperazines. Now introduce a scientific discovery about this category, Quality Control of 1-(4-Bromophenyl)-4-methylpiperazine.

Determination of residual solvents in paclitaxel by headspace gas chromatography

Background: A simple and sensitive gas chromatographic method was developed and validated for the simultaneous determination of methanol, ethanol, acetone, isopropyl alcohol, dichloromethane, N-hexane, ethyl acetate, tetrahydrofuran, and N,N-diisopropyl ethyl amine in Paclitaxel. A chromatographic separation was done on DB-624 column, 30m length x0.53mm ID, and film thickness 3 mu m, using a flame ionization detector (FID) with gradient column oven temperature program. The injection was carried out in split mode, with a split ratio of 5:1. A mixture of N-methyl-2-pyrrolidinone (contains 1% piperazine) and water in the ratio of 80:20 (v/v) was selected as a diluent to obtain good sensitivity along with the recovery. Results: The developed gas chromatographic method offers symmetric peak shape, good resolution of more than 2.0 between the solvent peaks, and the relative standard deviation for replicate injections of all the solvents were found to be not more than 15.0% with reasonable retention time for all the solvents. The limit of detection for methanol, ethanol, acetone, isopropyl alcohol, dichloromethane, N-hexane, ethyl acetate, tetrahydrofuran, and N,N-diisopropyl ethyl amine was found to be 304.69ppm, 497.98ppm, 498.99ppm, 504.49ppm, 61.81ppm, 30.07ppm, 505ppm, 73.05ppm, and 2.09ppm, respectively. Limit of quantitation of methanol, ethanol, acetone, isopropyl alcohol, dichloromethane, N-hexane, ethyl acetate, tetrahydrofuran, and N,N-diisopropyl ethyl amine was found to be 89.62ppm, 146.47ppm, 146.76ppm, 148.38ppm, 18.18ppm, 8.84ppm, 148.53ppm, 21.49ppm, and 0.62ppm, respectively. Precision was found to be satisfactory. Linear in the range of LOQ to 150% level for all the solvents, and accuracy along with robustness, is performed, and acceptable results were obtained. Conclusion: The proposed method was demonstrated to be simple, sensitive, specific, linear, precise, accurate, and robust, hence can be used to determine the residual organic solvents in Paclitaxel drug substance and drug product.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 16153-81-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Muresan-Pop, M., introduce new discover of the category.

Structural characterization of 5-fluorouracil & piperazine new solid forms and evaluation of their antitumor activity

A salt (FP-S) and two co-crystals (FP-C1 and FP-C2) of fluorouracil (FU) with piperazine (PZ) were investigated in terms of bioavailability and their effect on endothelial cells. From structural point of view, the best stability was observed for FP-C2 sample obtained by storage of FP-C1 sample under extreme conditions of temperature and humidity. This result was explained by the strong intermolecular interactions between 5-fluorouracil, piperazine and water, as denoted by the crystallographic analysis of FP-C2 form. Dissolution measurements in water indicate that the most soluble form is the salt, with a dissolution rate about 3 times greater than for the fluorouracil pure compound, while the solubility for co-crystals decreases compared to FU. Toxicity and antitumoral effect of the synthesized compounds were checked on three different cell lines: normal cells (HUVEC endothelial cells) and tumor cells (DLD-1 and HT29, both colorectal adenocarcinoma) and cytotoxicity by the MTT assay and cell proliferation assay. It has been found that the FP-C1 exerts a selective cytotoxic effect on HT29 cells and FP-C2 on DLD-1 cells in contrast to normal endothelial cell line resistance. For FU and FP-S salt, the effect on normal and tumoral cells is similar. The comparative study of the three fluorouracil forms shows that the best antitumor selective response was obtained for the co-crystal forms. (C) 2020 Elsevier B.V. All rights reserved.

Synthetic Route of 16153-81-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16153-81-4 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Sarmad, Shokat, once mentioned the application of 841-77-0, Product Details of 841-77-0, Name is 1-Benzhydrylpiperazine, molecular formula is C17H20N2, molecular weight is 252.3541, MDL number is MFCD00038379, category is piperazines. Now introduce a scientific discovery about this category.

Amine functionalized deep eutectic solvent for CO2 capture: Measurements and modeling

Deep eutectic solvents (DESs) have gained a great interest among researchers owing to their inherent advantages to become an adaptable alternative to ionic liquids (ILs) and common amine solutions for CO2 capture. In the present study, we prepared five new three-component DESs by functionalization of choline chloride-ethanolamine (1:7, mol:mol) DES using different types of amines: diethanolamine (amine type 2), methyldiethanolamine (amine type 3), piperazine (amine type 2) as well as 1-(2-aminoethyl)piperazine (amine type 1 and 2). All of the prepared DESs are liquid at room temperature and their melting points were in the range of 265-276 K. The solubility of CO2 in the studied DESs was measured at pressures up to 2 MPa and 298.15 K. The obtained experimental data were analyzed by the use of generic Redlich-Kwong equation of state (RK-EOS) model and Henry’s law constant have been calculated from the obtained experimental data through the EOS correlation. All the studied DESs show chemical absorption of CO2 which can be approved based on the excess enthalpy and Gibbs energy functions. FT-IR spectroscopy and C-13 NMR verified the formation of carbamate in the CO2 absorption process which revealed the chemisorption of CO2 in the studied DESs. The ideal association model has been utilized to describe the excess thermodynamic functions and two different types of the chemical association have been detected AB 2 and AB, (A refer to DESs and B to CO). 2 Based on the obtained solubility data, the amines that enhanced the absorption capacity of choline chloride-ethanolamine (1:7) follow the trend as follows: piperazine > aminoethylpiperazine > methyldiethanolamine > diethanolamine. Therefore, piperazine can be considered as an absorption enhancer. The viscosity of DESs before and after CO2 absorption as well as the thermal behavior of the DESs were also investigated. (C) 2020 Elsevier B.V. All rights reserved.

If you are interested in 841-77-0, you can contact me at any time and look forward to more communication. Product Details of 841-77-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 841-77-0, Name is 1-Benzhydrylpiperazine, formurla is C17H20N2. In a document, author is Faroughi Niya, Homayoun, introducing its new discovery. HPLC of Formula: C17H20N2.

Fe3O4@THAM-piperazine: a novel and highly reusable nanocatalyst for one-pot synthesis of 1,8-dioxo-octahydro-xanthenes and benzopyrans

A novel magnetically heterogeneous nanocatalyst has been successfully synthesized via the immobilization of piperazine on tris (hydroxymethyl) aminomethane-coated Fe3O4 magnetic nanoparticles. The described catalyst was fully characterized by various techniques such as FT-IR, EDS, DTG/TGA, XRD, TEM, SEM, and VSM analyses. The catalytic efficacy of Fe3O4@THAM-piperazine has investigated for one-pot synthesis of tetrahydrobenzo[b]pyran and 1,8-dioxo-octahydro-xanthene derivatives. Notable features of this user-friendly catalytic system include high yields, high catalytic activity, simple operation, non-toxicity, and easy work-up. Also, the new nanocatalyst could be easily recovered and reused for six times without significant loss of activity. [GRAPHICS]

If you are hungry for even more, make sure to check my other article about 841-77-0, HPLC of Formula: C17H20N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 841-77-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a article, author is Rezaei, Mohammad Taher, introduce new discover of the category.

Synthesis of a tertiary amine by direct reductive amination of a carbonyl compound to form a scorpionate ligand; formation of Mn (II), Zn (II) and Cd (II) complexes, DFT calculations and, molecular docking studies

A hexadentate, asymmetric tripodal scorpionate type ligand, [[N1-Pyridin-2-ylmethyl-N1-[2-(4-pyridine2-ylmethyl-piperazine-1-yl)-ethyl]-ethane-1,2-diamine]] (L) has been prepared. To form this ligand, the direct reductive amination of a carbonyl compound by NaBH4 was used for the synthesis of tertiary amine. The complexes [MnL])ClO4((2), [CdL])ClO4((2), [ZnL])ClO4((2) have also been prepared. The synthesized compounds were characterized by elemental analyses, FT-IR, ESI-MS and, NMR spectroscopy. An X-ray crystal structure of [MnL] (ClO4)(2), shows that the coordination environment around the manganese is a distorted trigonal prism. The nature of metal-ligand bonding in the complexes was investigated by Natural Bond Orbital analysis, Energy Decomposition Analysis and Energy Decomposition Analysis using Natural Orbitals for Chemical Valence variation. Molecular docking has been used for the biological evaluation of the anticancer and antioxidant activities of the synthesized compounds. The docking results indicated that the Cd, Mn, and Zn-complexes had the highest binding affinity (MolDock Score) for the binding sites of cytochrome P450, myeloperoxidase, and cytochrome P450, respectively. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 841-77-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 841-77-0 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Liu, Meihong, once mentioned the application of 5294-61-1, HPLC of Formula: C14H21N3O, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O, molecular weight is 247.34, MDL number is MFCD06384973, category is piperazines. Now introduce a scientific discovery about this category.

Carbodiimide-assisted zwitterionic modification of poly(piperazine amide) thin-film composite membrane for enhanced separation and anti-depositing performances to cationic/anionic dye aqueous solutions

In this work, a novel method of carbodiimide-assisted zwitterionic modification was proposed and implemented to incorporate zwitterionic moieties onto poly(piperazine amide) membrane for improved water permeability and anti-depositing property, which are crucial for highly efficient nanofiltration of dye-contained effluents. Carboxyl groups of polyamide layer were firstly transferred into N-acylurea using excess l-ethyl-3-(3-(dimethylamino)propyl)-carbodiimide. Zwitterions were then incorporated through ring-opening reaction between tertiary amine groups of N-acylurea and 1, 4-butanesultone. Carbodiimide-assisted zwitterionic modification was verified by ATR-IR and XPS analyses and was found to not affect membrane pore size but significantly enhance membrane’s permeation and antidye-deposition performances. Compared with those of virgin membrane, water permeabilities of the desired zwitterionic membrane to pure water, Congo red aqueous solution and Victoria blue B aqueous solution were higher by 42.9, 62.3 and 95.2 %, respectively, hydraulic resistances from irreversible deposition of Congo red and Victoria blue B molecules were dramatically lowered by 68.4 and 91.8 %, respectively. Furthermore, the perm-selectivity performance of the desired zwitterionic membrane in terms of molecular weight cut-off and pure water permeability was better than most of the reported zwitterionic membranes, and the separation and anti-depositing performances to both anionic and cationic dye aqueous solutions were better than commercial membrane NF270.

If you are interested in 5294-61-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C14H21N3O.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Liu, Caini, once mentioned the application of 147081-29-6, Formula: C10H20N2O2, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is C10H20N2O2, molecular weight is 200.278, MDL number is MFCD02683204, category is piperazines. Now introduce a scientific discovery about this category.

High-performance nanofiltration membrane with structurally controlled PES substrate containing electrically aligned CNTs

A structurally controlled polyethersulfone (PES) membrane, as the substrate of the thin film composite nanofiltration (NF) membranes, was designed and fabricated with aligned carbon nanotubes (ACNTs) by a direct current electric field. The morphology and properties of the NF membranes were simultaneously affected by the PES substrate with especial macrovoids and ACNTs, increasing the permeability from 6.4 to 29.7 L/m(2) h bar. It was confirmed by FT-IR and XPS that the poly(piperazine amide) selective layer of the modified NF membrane has an increased content of -COOH for enhanced hydrophilicity. The zeta potential proves that the surface of the NF membrane modified by electric field has weaker negative charge than that of unmodified membrane in the range of pH = 5-9. Under the combined action of the Donnan effect and size exclusion, the rejection of MgCl2 increased while maintaining the dianion rejection above 95%. Particularly, the NF membrane modified with ACNTs exhibited better chlorine resistance and antifouling ability, thus improving the stability and perdurability of membranes. Our work utilizes the characteristics of ACNTs to explore its potential in NF membranes.

If you are interested in 147081-29-6, you can contact me at any time and look forward to more communication. Formula: C10H20N2O2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is C8H18N2O6S2. In an article, author is Chouichit, Pakwilai,once mentioned of 5625-37-6, Safety of 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid.

A highly sensitive biosensor with a single-copy evolved sensing cassette for chlorpyrifos pesticide detection

A formylglycine-generating enzyme (FGE)-sulfatase-based whole cell biosensor was genetically improved into a single copy system by integrating the Sinorhizobium meliloti transcriptional activator ChpR and the chpA promoter-FGE-sulfatase fusion into the Escherichia coli chromosome. The sensitivity was further enhanced through a random mutagenesis of the chpR. The new integrated biosensor offered both a lower detection limit [5 nM chlorpyrifos (CPF)] and fluorescence background. The ready to use kit was developed using silica gel for on field detection. The biosensor kit was stable for 20 days when stored at 4 degrees C. Moreover, a 1-(1 naphthylmethyl)piperazine (NMP) efflux pump inhibitor can improve the sensitivity by 57%.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics