Month: March 2021

163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid (100mg, 0.254 mmol) in 2 mL of D F, was added HBTU (144 mg, 0.381 mmol) and DI PEA (0.177 mL, 1 .016 mmol). The reaction mixture was stirred at rt for 30 min, (R)-3-methyl-piperazine- 1 -carboxylic acid tert-butyl ester (76 mg, 0.381 mmol) was added and the resulting reaction mixture stirred for a further 2h at rt. The reaction was quenched with H20, and extracted with CH2CI2. The organic layer was washed with brine, dried over MgS04, filtered and evaporated under vacuum. The residue was dissolved in 3ml of CH2CI2 and TFA ( 1 ml) was added. The reaction mixture was stirred at ambient temperature for 2h. After this period of time, the mixture was concentrated and purified by preparative reverse phase Gilson H PLC and subsequent neutralization of the combined fractions over PL-HC03 MP gave the title compound (29 mg, 26% yield) as a white powder. 1H-N R (400 MHz, DMSO-d8, 298 K): delta ppm 1 .23 (d, 3 H) 2.55-3.2 (m, 7 H) 3.91 (s, 3H) 6.95 (d, 1 H) 7.62 (d, 1 H) 7.72 (t, 1 H) 7.81 (s, 1 H) 7.98 (d, 1 H) 8.1 1 (d, 1 H) 8.22 (d, 2 H) 8.38 (d, 1 H) 8.59 (s, 1 H) 9.38 (s, 1 H). MS: 440.1 [M-H ] Rt(2”= 0.89 min., 163765-44-4

163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOeGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; WO2013/88404; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.

SIK inhibitor II-1[00389] To a solution of 1-(6-chloropyrimidin-4-yl)-N-(2,6-dimethylphenyl)-1H- imidazol-2-amine (100 mg, 0.33 mmol) and 4-(4- ethylpiperazin-1-yl)aniline (68 mg, 0.33 mmol) in 2-butanol (1 mL) was added trifluoroacetic acid (TFA, 0.1 mL). The resulting mixture was stirred at 120 C for 4 h, concentrated, and diluted with dimethyl sulfoxide (6 mL). The resulting mixture was purified with preparative HPLC to afford 6-(2-((2,6- dimethylphenyl)amino)-1H-imidazol-1-yl)-N-(4-(4- ethylpiperazin-1-yl)phenyl)pyrimidin-4- amine TFA salt (78 mg, 41% yield) as an off-white solid. Rt = 1.93 min;1H NMR (600 MHz; DMSO-d6) 10.71 (br, 1H), 10.02 (s, 1H), 9.97 (br, 1H), 8.54 (s, 1H), 7.65 (s, 1H), 7.48 (d, J = 6.6 Hz, 2H), 7.20 (m, 4H), 7.10 (s, 1H), 7.01 (d, J = 9.0 Hz, 2H), 6.95 (s, 1H), 3.78 (m, 2H), 3.56 (m, 2H), 3.17 (m, 2H), 3.09 (m, 2H), 2.94 (m, 2H), 2.18 (s, 6H), 1.23 (m, 3H) ppm; MS m/z: 469.46 [M+1].

115619-01-7, The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; THE BROAD INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHAMJI, Alykhan; SUNDBERG, Thomas; GRAY, Nathanael; XAVIER, Ramnik; SCHREIBER, Stuart, L.; CHOI, Hwan, Geun; LIANG, Yanke; (315 pag.)WO2016/23014; (2016); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The appropriate 1-substituted piperazines (1 mmol)and Et3N (3 mmol) were added to a solution of 6-chloropurines(1mmol) (5, 6) in 5 mL of absolute EtOH. Themixture was refluxed for 8-16 h. The reaction mixture wasconcentrated in vacuo and the residue was purified by columnchromatography (EtOAC-hexane, 1:3 to 1:1).

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Atalay, Rengul Cetin; Guven, Ebru Bilget; Kucukdumlu, Asligul; Tuncbilek, Meral; Acta Chimica Slovenica; vol. 67; 1; (2020); p. 70 – 82;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

630125-91-6, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of methyl 4-chloro-3 -((8-(4-methoxybenzyl)-7-oxo-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yl)oxy)benzoate (step 1 intermediate) (210 mg, 0.46 mmol)and 4-((4-ethylpiperazin- 1 -yl)methyl)-3 -(trifluoromethyl)aniline (Intermediate Cl) (110 mg, 0.38 mmol) in toluene (3.0 mL) was dropwise added trimethyl aluminium solution (2M in toluene, 768 jiL, 1.54 mmol) at RT. The mixture was stirred for 3-5 h at RT. The mixture was quenched with aqueous ammonium chloride solution and extracted twice in ethyl acetate. Thecombined organic layers were washed with water followed by brine. The solution was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue thus obtained was purified by silica gel column chromatography to yield 115 mg of the desired product. ?H NMR (400 MHz, DMSO-d6) oe 0.99 (t, J = 7.2 Hz, 3H), 2.40-2.5 1 (m, 1OH), 3.57 (s, 2H), 3.72 (s, 3H), 5.04 (s, 2H), 5.15 (s, 2H), 6.87 (dd, J, = 2.0 Hz, J2 = 6.4 Hz,2H), 7.31 (d, J= 8.8 Hz, 2H), 7.72 (d, J= 8.4 Hz, 1H), 7.83 (d, J= 8.4 Hz, 1H), 7.94-8.0 (m,3H), 8.17 (s, 1H), 8.22 (s, 1H), 10.58 (s, 1H); ESI-MS (m/z) 711 (M+H)., 630125-91-6

630125-91-6 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 59134564, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; PATEL, Vinod; REDDY, Venkateshwar; GHARAT, Laxmikant Atmaram; CHAUDHARI, Sachin Sundarlal; DAS, Sanjib; VELGALETI, Ranganadh; SHAH, Daisy Manish; BAJPAI, Malini; (262 pag.)WO2018/215668; (2018); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: Compounds 1a-l and compounds 15-19 were synthesized in the same reaction: In a dichloromethane solution (2-3 mL) of chloroacetylchloride(1.1 eq), a dichloromethane solution (8-10 mL) of the appropriate piperazine (1 eq) and triethylamine (2.5 eq) was added dropwise and the reaction mixture was stirred overnight at room temperature under a nitrogen atmosphere. The reaction mixture was evaporated and the residue was extracted with ethylacetate-brine. The organic layer was dried over Na2SO4 and chromatographed on silica preparative TLC to give the desired products.When the reaction was run for 2 h, compounds 1a-l were the mainproducts (>90%)., 30459-17-7

As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.

Reference£º
Article; Papadopoulou, Maria V.; Bloomer, William D.; Rosenzweig, Howard S.; O’Shea, Ivan P.; Wilkinson, Shane R.; Kaiser, Marcel; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 325 – 334;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.

934-98-5, (Z)-4-(((l -Acetyl-6-(methoxycarbonyl)-5-methyl-2-oxoindolin-3-ylidene) (phenyl) methyl)amino)benzoic acid, trifluoroacetate adduct (Intermediate E) (75 mg,0.128 mmol), and HATU (73 mg, 0.192 mmol) in DMF (2 mL) were stirred at rt for 10 mm then Hunig?s base (179 p1, 1.03 mmol) and 2-(4-methylpiperazin-1-yl)ethanamine (50 mg, 0.346 mmol) in DMF (0.5 mL) were added. The mixture was stirred at rt for 3 h and piperidine (127 p1, 1.28 mmol) was added. The mixture was stirred at rt for 18 h. The reaction mixture waspartitioned between DCM (25 mL) and saturated aqueous NaHCO3 solution (10 mL). The organic layer was washed with brine (10 mL) and the solvent was evaporated under reduced pressure. The crude product was purified by preparative HPLC (Method A, 20-50percent MeCN in water) to afford the title compound (Z)-methyl 5-methyl-3-(((4-((2-(4-methylpiperazin-1- yl)ethyl)carbamoyl)phenyl)amino) (phenyl)methylene)-2-oxoindoli ne-6-carboxylate as a lightyellow solid (19 mg, 25percent); Rt 1.46 mm (Method 1); mlz 554 (M+H) (ES); 1H NMR delta: 2.13(3H, 5), 2.21 (3H, 5), 2.32-2.46 (8H, overlapping m), 3.27-3.34 (4H, overlapping m), 3.75 (3H,5), 5.62 (1H, 5), 6.87 (2H, m), 7.36 (1H, 5), 7.52 (2H, m), 7.56-7.69 (5H, overlapping m), 8.26(1H, t), 10.87 (1H, 5), 12.22 (1H, 5).

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; RESPIVERT LIMITED; WALTERS, Iain; BIRCH, Louise; COLLINGWOOD, Stephen, Paul; STEVENSON, Christopher, Scott; (110 pag.)WO2017/153748; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.

In N2 Under protection, three-necked flask with stirring and the funnel was added dropwise and THF150ml 100mmol isopropyl piperazine, in an ice bath, was slowly added dropwise through a dropping funnel 100mmol butyllithium dropwise after l to room temperature, the reaction after 1h.Under a 71/92 then cooled to 0¡ãC 100mmol cyclohexyl trimethoxysilane, after the completion of the dropwise addition the reaction at room temperature for 8h, and finally through G4Funnel, the solid residue was washed repeatedly with tetrahydrofuran and filtered, the filtrate was collected.With a rotary evaporator to tetrahydrofuran solvent, vacuum distillation, collecting 136 ~ 139¡ãC / 100pa fraction.Vacuum distillation, collecting 136 ~ 139¡ãC/ 100pa distillate, heavy 5.3g, 98.2percent yield,

As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.

Reference£º
Patent; Institute of Chemistry Chinese Academy of Sciences; Li, Huayi; Chang, Hefei; Zhang, Liaoyun; Hu, Youliang; (19 pag.)CN102977133; (2016); B;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

STR20 3 g (0.01 mole) of the product from Example B are heated under reflux in 25 ml of pyridine with 4 g (0.04 mole) of 2-methyl-piperazine for 5 hours. The mixture is concentrated in vacuo, 20 ml of water are added, the pH is brought to 5 with 2N hydrochloric acid and the precipitate which separates out is recrystallized from methanol. 0.6 g (16% of theory) of 8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid of melting point 318-325 C. (with decomposition) is obtained.

109-07-9, As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference£º
Patent; Bayer Aktiengesellschaft; US4703047; (1987); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

74879-18-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of bromobenzene (300 mg), (S)-2-methylpiperazine (230 mg), (S)-(-)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) (48 mg), sodium tert-butoxide (266 mg), tris-(dibenzylideneacetone)dipalladium(0) (26 mg) and toluene (15 ml) was stirred at 100 C. for 4 hours under a nitrogen atmosphere. The mixture was cooled to room temperature and saturated aqueous sodium hydrogencarbonate solution was added thereto. The organic layer was separated, washed with brine and dried over magnesium sulfate. The solvent was removed under reduced pressure. The obtained crude product was purified by silica gel column chromatography (chloroform-methanol 20:1) to give the title compound in a pure form. [00204] 1H-NMR (300 MHz, CDCl3) delta 1.11 (d, J=6 Hz, 3H), 2.37 (dd, J=12 Hz,1 Hz, 1H), 2.72 (td, J=12 Hz,3 Hz, 1H), 2.95-3.18 (m, 3H), 3.52 (d, J=12 Hz, 2H), 6.82-6.98 (m, 3H), 7.22-7.29 (m,2H).

The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6825200; (2004); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.655225-01-7,tert-Butyl 4-(2-bromoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Step 1 : A mixture of lb (4.85g, 16.5mmol) and 9a (16.5g, 0.33mol) in ethanol (50mL) was heated under reflux overnight, then evaporated under high vacuum. The residue was re-dissolved in ethanol and the resulting precipitate was filtered off. The filtrate was concentrated and dried to give crude 9b (4.02g, ca. 100percent).

655225-01-7, As the paragraph descriping shows that 655225-01-7 is playing an increasingly important role.

Reference£º
Patent; TYROGENEX, INC.; LIANG, Congxin; WO2011/41399; (2011); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics