Month: March 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5

c) 4-r (4-MethoXvphenyl) amino1-N-r2-(4-methvlpiperazin-1-vl) ethyl1benz- amide; 97.3 mg (0.4 mmol) of the compound prepared in Example 6b are added to a suspension of 400 mg of commercial triphenylphosphine on polymer (3 mmol/g) in 1.1 ml of dichloromethane, followed by addition of 0.048 ml (0.48 mmol) of tri- chloroacetonitrile. After stirring for 3 hours at room temperature, the reaction medium is filtered and the filtrate is poured into a suspension of 329.7 mg of commercial N-methylmorpholine on polymer (3.64 mmol/g) and 62.9 mg (0. 4 mmol) of 2- (4-methylpiperazin-1-yl) ethylamine in 2.2 ml of THF. The new suspension is stirred for 16 hours at room temperature and then filtered. The fil- trate is concentrated under vacuum to give 110 mg of solid. (Yield: 74.6percent). NMR (CDCl3) : 1.8 (2H, m); 2.25 (3H, s); 2.4-2. 8 (8H, m); 3.5 (2H, m); 3.8 (3H, s); 5.8 (1 H, s); 6.8 (4H, m); 7.05 (2H, m); 7.5-7. 7 (3H, m).

934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; WO2003/76406; (2003); A1;,
Piperazine – Wikipedia
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5271-27-2, 1-Methyl-3-phenylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5271-27-2, -Methyl-3-phenylpiperazine (17.6 g; 0.1 mol) was dissolved in 100 dichloromethane. Triethylamine (15 ml; 0.1 mol) was added. A solution of propionyl chloride (10 g; 0.11 mol) in dichloromethane was slowly added under cooling. After the total addition a wh

As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; WO2007/144409; (2007); A1;,
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57184-23-3, 1-(Cyclohexylmethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Die nachfolgenden Verbindungen der Beispiele 8 bis 65 wurden nach einem automatisierten Herstellungsverfahren hergestellt.Hierzu wurde pro Ansatz eine Loesung von 0,03 mmol (2R)-1-[3,5- Bis(trifluormethyl)benzoyl]-2-(1H-indol-3-ylmethyl)-4-(4-azido-2-butin-1-yl)piperazin der Formel IV (Herstellung siehe Beispiel 1/Syntheseweg 1B)) in 1 ml Ethylacetat jeweils mit einer Loesung von 0,03 mmol des als Reaktionspartner vorgesehenen sekundaeren Amins der Formel V in 1 ml Ethylacetat umgesetzt und anschliessend mit 3 ml Ethylacetat verduennt. Auf das Reaktionsgemische wurde Stickstoffgas gegeben und es wurde jeweils 6 Stunden lang bei 70 C geruehrt. Der Reaktionsendpunkt wurde Duennschicht-chromatographisch bestimmt. Nach vollendeter Umsetzung wurden die einzelnen Reaktionsgemische jeweils im Vakuum zur Trockene eingedampft. Aus dem Rueckstand wurde ohne weitere Aufreinigung jeweils eine Probe fuer die Hochleistungs-Fluessigkeitschromatographie (= HPLC) und fuer die automatische Massenspektroskopie zur Bestimmung der Reinheit bzw. zur Strukturbestaetigung entnommen., 57184-23-3

The synthetic route of 57184-23-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Solvay Pharmaceuticals GmbH; EP1176144; (2002); A1;,
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Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-bromobenzonitrile 12 (1.5 g, 8.24 mmol) in toluene, N-methylpiperazine (1.4mL, 12.36 mmol), sodium tert-butoxide(1.19 g, 12.36 mmol), Tris(dibenzylideneacetone)dipalladium(0) (0.023 g, 0.02mmol), and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) (0.036 g, 0.05mmol) were added. The reaction mixture was heated at 80 C for 16 hours andthen filtered on celite pad. The organic phase was evaporated under reducedpressure. The brown oil was purified by flash chromatography on silica gel(Eluent: CH2Cl2:MeOH 9:1). Compound 13 was obtained as a yellow oil (60%). 1H NMR (400 MHz,CDCl3): delta(ppm) 2.25(s, 3H); 2.46(t, J=8, 4H); 3.25-3.23(t, J=8, 4H);6.76(d, J=8, 2H); 7.39(d, J=8, 2H). Anal. Calcd. for C12H15N3:C, 71.61; H, 7.51; N, 20.88; found: C, 71.21; H, 7.21; N, 20.78

109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Radi, Marco; Bernardo, Vincenzo; Vignaroli, Giulia; Brai, Annalaura; Biava, Mariangela; Schenone, Silvia; Botta, Maurizio; Tetrahedron Letters; vol. 54; 38; (2013); p. 5204 – 5206;,
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Piperazines – an overview | ScienceDirect Topics

208167-83-3, tert-Butyl 4-(2-chloroethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N-(cyclohexylmethyl)-8-hydroxy-4-oxo-chromene-2-carboxamide (45 mg, 0.15 mmol) in DMF (2 ml_), potassium carbonate (48 mg, 0.34 mmol) was added and after 20 minutes fert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate (58 mg, 0.22 mmol) was also added and the reaction was stirred in a microwave reactor at 100 C for 1h. After that time LC-MS (ESI) analysis confirmed complete conversion of the starting material into desired intermediate product. The reaction mixture was then filtered and evaporated to give the crude intermediate material which was then purified further using flash column chromatography eluting with 0-10% MeOH in DCM to give iert-butyl 4-[2-[2-(cyclohexylmethylcarbamoyl)-4-oxo-chromen-8-yl]oxyethyl]piperazine-1 – carboxylate (23 mg, 0.04 mmol), in a 28% yield and as a white solid. LC-MS (ESI) analysis of the so-purified product was consistent with the desired product and the material was then taken directly into the next step, conversion to intermediate compound of general formula (V) without further analysis. LC-MS (ESI) m/z 514 [M + H]+., 208167-83-3

The synthetic route of 208167-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNIVERSITY OF DUNDEE; FORTE, Barbara; NORCROSS, Neil; JANSEN, Chimed; BARAGANA, Beatriz; GILBERT, Ian; CLEGHORN, Laura; DAVIS, Susan; WALPOLE, Christopher; (194 pag.)WO2017/221002; (2017); A1;,
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Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

2-(piperazin-1-yl)ethan-1-ol (5 g, 38.41 mmol, 1.00 equiv) was dissolved inDCM (100 mL), and a solution of di-tert-butyl dicarbonate (8.38 g,38.40 mmol, 1.00 equiv) in DCM (20 mL) was added drop-wise. The reaction was left under agitation overnight at ambient temperature. The reaction was evaporated to dryness and the residue dissolved in 200 mL of AcOEt, washed 5 times with NaC1 (sat.), dried over sodium sulfate, filtered and concentrated under reduced pressure toyield 8.5 g (96 %) of compound 45A in the form of a white solid., 103-76-4

103-76-4 N-(2-Hydroxyethyl)piperazine 7677, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; PIERRE FABRE MEDICAMENT; PEREZ, Michel; RILATT, Ian; LAMOTHE, Marie; WO2014/174062; (2014); A1;,
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Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 55-chloro-N-[2-(4-methylpiperazin-1-yl)ethyl]-3-phenyl-1H-indole-2-carboxamideTo a DMF solution (1 mL) containing commercially available 5-chloro-3-phenyl-1H-indole-2-carboxylic acid (100 mg), 2-(4-methylpiperazin-1-yl)ethylamine (52 mg) and HATU (141 mg), diisopropylethylamine (0.2 mL) was added and the resulting solution was stirred overnight at room temperature.Water was added to the reaction solution and the solution was extracted with chloroform.After the chloroform layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and the resulting residue was purified by NH-silica gel column chromatography (hexane:ethyl acetate=1:1), whereby the title compound (100 mg) was obtained as a yellow solid.1H-NMR (400 MHz, CDCl3, deltappm): 2.22-2.32 (8H, m), 2.23 (3H, s), 2.36 (2H, t, J=5.8 Hz), 3.44 (2H, dt, J=5.8, 5.8 Hz), 6.52 (1H, br s), 7.25 (1H, m), 7.41 (2H, m), 7.51 (5H, m), 9.89 (1H, s).ESI-MS Found: m/z 397[M+H]+

934-98-5, 934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MSD K.K; US2012/28990; (2012); A1;,
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Piperazines – an overview | ScienceDirect Topics

1072027-36-1, 4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4a-4c (1mmol) suspended in methanol (1mL) was added 4M HCl in dioxane (5mL) and the reaction mixture was stirred for 24hat room temperature. The precipitate was filtrated, washed with diethyl ether (2¡Á5mL), and dried to obtain 5a-5c, which were used for the next step without further purification.

1072027-36-1, The synthetic route of 1072027-36-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Yang; Yin, Yanzhen; Zhang, Zhen; Li, Carrie J.; Zhang, Hui; Zhang, Daoguang; Jiang, Changying; Nomie, Krystle; Zhang, Liang; Wang, Michael L.; Zhao, Guisen; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 543 – 551;,
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Piperazines – an overview | ScienceDirect Topics

438631-77-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.438631-77-7,(R)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

(R)-l-(4-Chlorophenyl)-piperazine-2-carboxylic acid methyl esterR-4N-Boc-piperazine 2-carboxylic acid methyl ester (4.0gms, 16.4mmol) and 4- chlorophenylboronic acid (5.0gms, 32.8mmol) are mixed in dichloromethane (5OmI) . followed by addition of cupric acetate (3.0gms, 16.4mmol), 4 A molecular sieves (1 gm) and pyridine (3.28ml, 32.8mmol). The mixture is stirred at room temperature for 50 hr. The reaction mixture is concentrated directly in vacuo, diluted with ethyl acetate, and filtered through Celite. The organic filtrate is concentrated and the remaining residue is purified over silica gel column chromatography eluting with hexane and ethyl acetate to give 860 mg as a white solid.

As the paragraph descriping shows that 438631-77-7 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2007/120595; (2007); A2;,
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Piperazines – an overview | ScienceDirect Topics

1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound IX 20.3 g (0.064 mol), 15.8 g (0.13 mol) DMAP, 20.9 g were added to a 2 L reaction flask.(0.11 mol) EDCI and 500 mL dichloromethane (DCM),The system was stirred at 20 C.A solution of 37.5 g (0.064 mol) of compound VIII and 23.7 g (0.23 mol) of triethylamine and 200 mL of dichloromethane prepared in advance was slowly added dropwise to the above system.After the completion of the dropwise addition, the mixture was stirred at 20 C for 3 hours, and then controlled by HPLC or TLC. The starting material was completely reacted.To the system was added 14.1 g of N,N’-dimethylethylenediamine.The system is heated to 35 C and stirring is continued.After the temperature is stable, add 200 mL of 12% acetic acid solution.After stirring for 10 min, the layers were separated, and the organic layer was washed with 5% sodium hydrogen carbonate solution (200 mL) and then washed with 5% sodium chloride solution (200 mL).The organic layer was dried, filtered, and evaporated to dryness.After the system is heated to 30 C, the methanol solution is added dropwise.After the system is clarified, start to cool down to 0-5 C, and stir for 1 h.After filtration, the cake was dried to give a white solid compound I about 50.8 g.The yield is 91.4%,, 1235865-77-6

The synthetic route of 1235865-77-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangsu Zhongbang Pharmaceutical Co., Ltd.; Huang Shuang; Yang Jian; Wu Xiaogang; Shi Lingyun; Liu Liping; (21 pag.)CN108997333; (2018); A;,
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Piperazines – an overview | ScienceDirect Topics