Month: March 2021

Reference of 147081-29-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Marupati, Siddhartha, introduce new discover of the category.

Synthesis, in vitro and in silico studies of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl)(pyridin-2-yl)methanone and its derivatives

A series of cis-2,6-dimethyl-4-(1-phenyl-1H-thieno[3,2-c]pyrazol-3-yl)piperazin-1-yl) (pyridin-2-yl)methanone and its derivatives (8a-g) was synthesized by the reaction of cis-3-(-3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-thieno [3,2-c] pyrazole hydrochloride (7) with substituted picolinic acid (5) in the presence of hexafluorophosphate azabenzotriazole tetramethyl uronium and N,N-diisopropylethylamine. All the compounds were thoroughly characterized by spectral and elemental analysis. They have been screened for their antibacterial activity and docking results of title compounds have been presented.

Reference of 147081-29-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

30459-17-7, 1-(4-Trifluoromethylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: At first, THF (2.0 mL) was added to a mixture of oxabenzonorbornadiene 1 (0.347 mmol, 1.0 equiv), amine 4 or 6 (1.041 mmol, 3.0 equiv), NaI (10.34 mg, 0.069 mmol, 0.2 equiv), ligand L2 (4.5 mg, 0.0167 mmol, 4.8 mol %) and [Rh(C2H4)2Cl]2 (2.7 mg, 0.0069 mmol, 2.0 mol %) under N2. The mixture was then stirred at RT for 1 h and heated at reflux for 6-12 h after which the residue was subjected directly to silica gel column chromatography [ethylacetate/hexanes (1:1-2:1 v/v) as the eluent] to afford the desired alcohol product 5 or 7. The enantioselectivity was determined by chiral HPLC on a chiralcel OD-H, chiralcel AD-H, or Lux Amylose-2 column.

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Luo, Renshi; Xie, Ling; Liao, Jianhua; Xin, Hu; Chan, Albert S.C.; Tetrahedron Asymmetry; vol. 25; 9; (2014); p. 709 – 717;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1. Preparation of 3,5-dimethyl-1-tert-butoxycarbonyl-piperazine (ZTH-1): [0025] Adding 2,6-lupetazin (11.4 g, 100 mmol, 1 eq) and di-tert-butyl dicarbonate (21.8 g, 100 mmol, leg) into a 250 ml flask; and then adding 100 ml tetrahydrofuran, reacting under room temperature for 4 hours; and condensing up tetrahydrofuran (i.e., condensing tetrahydrofuran until used up), 21.4 g orange-colored oily substance ZTH-1 is obtained, wherein the yield is 100%.

21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhang, Nan; Zhong, Rong; US2013/116265; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1403898-64-5, (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DIPEA (1.517 mL, 8.68 mmol) was added to 505 7-bromo-4-chloro-6,8-difluoro-3-nitroquinoline (702 mg, 2.17 mmol) and 180 tert-butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (500 mg, 2.17 mmol) in 78 THF (8 mL) at 25 C. The resulting solution was stirred at 80 C. for 4 h. The solvent was removed in vacuo. The crude product was purified by flash silica chromatography (10 to 50% 57 EtOAc in 148 petroleum ether) to afford 732 tert-butyl (2R,5R)-4-(7-bromo-6,8-difluoro-3-nitroquinolin-4-yl)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (861 mg, 77%) as a yellow solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.21 (3H, d), 1.44 (9H, s), 2.84-3.00 (1H, m), 3.27-3.34 (1H, m), 3.47-3.68 (2H, m), 3.70-3.84 (2H, m), 3.97-4.08 (1H, m), 4.21-4.33 (1H, m), 4.64 (1H, t), 7.92 (1H, dd), 9.02 (1H, s); m/z: ES+ [M+H]+=517., 1403898-64-5

As the paragraph descriping shows that 1403898-64-5 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59878-57-8, (4) The product of the previous step (0.3 g, 1 mmol) was weighed, dissolved in 5 mL of dichloromethane, and trimethylacetyl chloride (121 yL, 1 mmol) and triethylamine (208 mL, 1.5 mmol) were stirred at room temperature. The reaction was clarified until the solution was clarified. 1 – (cyclopropylcarbonyl)-pyridazine (0.3 g, 2 mmol) was dissolved in 5 mL of ethanol, added dropwise to the above clear solution, reacted at room temperature for 4 h, and extracted with dichloromethane (15 mL). The organic phase was washed with water, and the organic layer was dried over anhydrous sodium sulfate, and then evaporated to dryness to afford ololani (0.4 g, 0.9 mmol), yield 91.5%, purity 99.8%.

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference£º
Patent; Beijing Yaocheng Huiren Technology Co., Ltd.; Qiao Hongwei; Bian Weiguang; Li Qiaoying; (9 pag.)CN108129397; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.892242-64-7,4-((3-(4-Cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acid,as a common compound, the synthetic route is as follows.,892242-64-7

Example 3 Preparation of sodium 4-((3-(4-cvciohexyipiperazin- I -yfl-6-oxo-6H-anthraj I 9-cdIisoxazol-5- yflamino)benzoate, About SOg of 4-((3-(4-cyclohexyipiperazin- 1 -yl)-6-oxo-6H-anthra[ 1 ,9- cd]isoxazol-5-yl)arnino)henzoic acid was slurred in 2500mL of 0.4 M NaOH/MeOH between 40-45C for 2-4 hours, After confirmed the reaction completion by FIPLC, slowly cooled thereaction to room temperature. The solid was centrifuged and washed with 2OmL of MTBE. The wet cake was re-suspended in about i000mL of O.1M NaOH in MeOH solution under room temperature. It was centrifuged and washed with 224rnL of MTBE again. The filtered solid was suspended in 996nTh of MTBE under room temperature for I -2 hours. The solid was separated and dried at 2530C under pressure for 12-24 hours to obtain the final desired product withpurity more than 99% and about 90% yield. Mass spectra give [M-?-I = 523.2. ?H-NMR (400MHz, DMSO-d6, see Figure 3), ppm (oe): 11.79 (IH, s), 8.48 (111, d), 8.20 (1H, ci), 7.93 (2Ff, d),7.84 (114, t), 7.72 (IH, t), 7.35 (2H, d), 6.39 (1 Fl, s), 3.85 (4ff m), 2.72-2.70 (414, in), 2.28-2.265(IF, m), 1.72-1.78 (4H, in), 1.55-1.58 (IN, m), 1.08-1.23 (SF1, m). Sodium content is 3.8%. TheRaman spectrum is shown in Figure 5. The XRPD, see Table below and Figure 4, confirmed thepolymorphic form.

892242-64-7 4-((3-(4-Cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acid 3666186, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; VM PHARMA LLC; WU, Jay Jie-Qiang; WANG, Ling; (83 pag.)WO2016/43975; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

259808-67-8, 1-Boc-3,3-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tert-butyl 3,3-dimethylpiperazine-1-carboxylate (413 mg, 1.65 mmol) was dissolved in DCE (15 mL). TEA (1.148 mL, 8.23 mmol) was added, followed by cyclobutanone (231 mg, 3.29 mmol) and sodium triacetoxyborohydride (524 mg, 2.47 mmol). The reaction mixture was stirred for 5 h and a few drops of acetic acid were added. The reaction mixture was heated at 40 C. for 4 days, cooled to rt, washed with sat NaHCO3, dried over MgSO4, filtered and concentrated under reduced pressure to give a dark yellow oil. The crude title compound was used in the next step without further purification.

259808-67-8, As the paragraph descriping shows that 259808-67-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; US2010/216812; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5747-48-8,11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine,as a common compound, the synthetic route is as follows.

A toluene solution of ll-piperazin-l-yldibenzo[b,f][l,4]thiazepine (1500 mL, 0.686 mol) prepared by reaction of piperazine with ll-chloro-dibenzo[b,f][l,4]-thiazepine in toluene (see, e.g., U. S. Pat. No. 4,879,288) was treated with 1500 mL deionized water and 90 mL of HCl (32% w/w). The resulting mixture was heated to 70 0C and agitated for 45 min. Agitation was ceased and the mixture allowed to settle and phase separate for 30 min. The lower aqueous phase, containing the HCl salt of ll-piperazin-l-yldibenzo[b,fj[l,4]thiazepine was isolated. The aqueous phase was then treated with 1000 mL of toluene and 99 g of aqueous NaOH (47% w/w). The resulting mixture was heated to 70 C and agitated for 45 min. Agitation was ceased and the mixture allowed to settle and phase separate for 30 min. The lower aqueous phase was discarded and the upper organic phase retained to which 300 mL of deionized water was added. The resulting mixture was agitated for 15 min and then allowed to settle for 30 min. The aqueous phase was discarded and the organic phase retained. The organic phase was extracted once more with 300 mL of deionized water. About 750 mL of toluene from the organic phase was distilled out. The resulting concentrate was cooled to 60 C, then 200 mL of methyl-t-butyl ether (MTBE) was added. The resulting mixture was cooled to ambient temperature then seeded with Form A seed crystals. The seeded mixture was then cooled to 10 C and held at this temperature for 3 hours under slow agitation. The resulting solid was isolated under suction via a no. 3 sinter. The solid product was then washed with 170 mL of MTBE at ambient temperature and dried at 40 C under vacuum resulting in 175 g (86.4%) of crystalline product. Assay by NMR 95.1 % w/w.Solid ll-piperazin-l-yldibenzo[b,fj[l,4]thiazepine (30 g, 0.1016 mol) prepared as described above was slurried in isopropanol (120 mL). The resulting mixture was warmed to about 63-64 0C to completely dissolve the solid. The resulting solution was filtered through a preheated (about 55 0C) split Buchner funnel fitted with filter paper with a pore size of 6 Dm. The filtered solution was then adjusted to 55 C and seeded with seed crystals of Form A (0.024 g). The seeded solution was maintained at 55 0C for about 2 h then linearly cooled to 40 C over the course of 6 h, linearly cooled to 20 0C over the course of 2 h, and then linearly cooled to 0 0C over the course of 1 h. The resulting slurry was held at 0 0C for 12 h and the filtered to give a solid product cake (13 mm high x 68 mm diameter). The product cake was displacement washed with 30 niL isopropanol prechilled to 0 C and the cake allowed to deliquor. The product was then dried at 40 0C under vacuum yielding 24.9 g (83%) of Form A. Assay by NMR: 98.9% w/w., 5747-48-8

Big data shows that 5747-48-8 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; WO2007/62337; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118753-66-5,tert-Butyl 4-aminopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

(1) 4-Amino-1-tert-butoxycarbonylpiperazine (3.00 g), 4-fluoronitrobenzene (2.54 g) and N,N-diisopropylethylamine (8.82 g) were dissolved in N-methyl-2-pyrrolidone (30 mL), and the mixture was stirred at 80C for 18 hr. The reaction mixture was added to water and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give 1-tert-.butoxycarbonyl-4-(4-nitrophenyl)aminopiperidine (2.55 g) as a white solid.

118753-66-5, 118753-66-5 tert-Butyl 4-aminopiperazine-1-carboxylate 22029174, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; WELFIDE CORPORATION; EP1308439; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

57260-71-6,57260-71-6, tert-Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Boc-piperazine (P/N: Lancaster L13363, 500 mg, 2.68 mmol) in DCM(30 ml) was added succinic anhydride (269 mg, 2.68 mmol). The reaction was stirred for 2 hours at ambient temperature. TLC analysis showed formation of succinylated Boc-piperazine (Rf= 0.50; 9:1:0.01 DCM-MeOH-AcOH, TLC developed by heating with 3% (w/v) solution of ninhydrin in EtOH). To this solution was added TFA (30 mL) and the mixture was then stirred for 1 h at ambient temperature. The volatile components of the mixture were removed under reduced pressure and the resulting oil dissolved in THF (30 mL) with minimum amount of water and adjustment of the pH to 9 by the addition of DIPEA. A solution of Fmoc-OSu (907 mg, 2.69 mmol) in THF (10 mL) was added and stirred for 1 h at ambient temperature. TLC analysis showed formation of a product (Rf = 0.55; 9:1:0.01 DCM-MeOH-AcOH, UV 254 nm, TLC developed by heating with 3% (w/v) solution of ninhydrin in EtOH). The volatile components of the mixture were then removed under reduced pressure and the resulting oil was dissolved in minimum volume of saturated NaHCO3. The aqueous solution was then extracted with Et2O (100 mL x 2), acidified (pH ~1) with HCI (1 M) and re-extracted with EtOAc (150 mL x 2). The combined EtOAc layers were dried over Na2SO4 and concentrated to give the product as colorless oil.

57260-71-6 tert-Butyl piperazine-1-carboxylate 143452, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; APPLERA CORPORATION; WO2007/87534; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics