Month: March 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3-iodo-4-methylbenzoyl chloride obtained above in dry DCM (10mL) at 0C was added Et3N (0.28mL, 2.0mmol) and 4-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) aniline (328mg, 1.2mmol). The mixture was stirred at room temperature for 5h, and then the solvent was removed under reduced pressure. The residue was purified by using column chromatography to afford the corresponding product 6-1 (439mg, 2 steps yield: 85%)., 694499-26-8

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Reference£º
Article; Liu, Yang; Peng, Xia; Guan, Xiaocong; Lu, Dong; Xi, Yong; Jin, Shiyu; Chen, Hui; Zeng, Limin; Ai, Jing; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 122 – 132;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine. In a document, author is Nasir, Qazi, introducing its new discovery. Product Details of 300543-56-0.

A Hybrid Membrane-Absorption Process for Carbon Dioxide Capture: Effect of Different Alkanolamine on Energy Consumption

Amine and membrane-based processes are commonly used to treat acid gases such as carbon dioxide and hydrogen sulfide. Carbon dioxide adversely affects the environment, therefore, its utilization and storage are critical. In this work, a simplistic approach of single-stage membrane units combine with amine absorption processes with different commercial amines was investigated. An increase in CO2 concentration in the feed gas results in a substantial increase in the thermal energy consumption of the stripper reboiler were using a hybrid amine-membrane setup can effectively reduce energy consumed in the reboiler. Both the amine absorption process and membrane process are simulated using Aspen HYSYS V10. Since the membrane is not available in Aspen HYSYS V10 unit operation package; it is programmed and added as custom user operation. Moreover, a new acid/ amine-based fluid package builds in a combination of the Peng-Robinson equation of state for vapor phase and electrolyte non-random two liquid-based activity model for the liquid phase were used in this study. Furthermore, energy consumption in CO2 capture using different alkanolamine such as N-methyldiethanolamine (MDEA), monethanolamine (MEA), deithanolamine (DEA), piperazine (PZ), triethanolamine (TEA) are also studied. As membrane unit help in CO2 reduction in feed to amine absorption process in hybrid amine-membrane setup. This significantly reduces the energy requirement as compared to the conventional standalone alkanolamine process. In comparison with various amines used in the amine absorption process, MEA offers the lowest total energy consumed, whereas, MDEA is considered to be the highest in terms of energy consumption.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O, belongs to piperazines compound, is a common compound. In a patnet, author is Chamakuri, Srinivas, once mentioned the new application about 5294-61-1, Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines

A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from alpha-amino acids, within four steps chiral 2-substituted piperazines are obtained. The key transformation involves an aza-Michael addition between an orthogonally bis-protected chiral 1,2-diamine and the in situ generated vinyl diphenyl sulfonium salt derived from 2-bromoethyl-diphenylsulfonium triflate. Further validation using different protecting groups as well as synthesis on multigram scale was performed. The method was also applied to the construction of chiral 1,4-diazepanes and 1,4-diazocanes. Additionally, the method was utilized in a formal synthesis of chiral mirtazapine.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, in an article , author is Liu Cui-mei, once mentioned of 300543-56-0, Recommanded Product: 300543-56-0.

Rapid Qualitative Analysis of New Psychoactive Substances by Infrared Spectroscopy

In this study, the infrared spectra (IR) of 301 new psychoactive substances (NPS) reference substances, including 100 synthetic cannabinoids, 81 synthetic cathinone, 42 phenethylamines, 9 tryptamines, 5 piperazines, 7 phencyclidine-type substances, 2 aminoindanes, 55 other types, were analyzed. The discriminant ability of IR for NPS, especially for NPS structural analogues, was investigated. The result showed that IR could well distinguish all kinds of NPS, even for some analogues with high spectrum similarity. IR has a high discrimination ability for 97% NPS, including alkyl chain-substituted regioisomers, ring-substituted regioisomers, different benzene ring disubstituted analogues, etc. The matching coefficient method is commonly used for spectral library search. The calculated matching coefficient value depends on several factors such as the quality of spectrum, software, algorithm, etc. so it is difficult to determine a universal threshold for positive detection. Therefore, the matching coefficient method can be only used for preliminary screening. Compared with the matching coefficient method, the characteristic peak method is more accurate and reliable for qualitative identification. Generally, eight absorption peaks with relatively high intensity in the range of 2500 similar to 650 cm(-1) are selected as characteristic peaks, but for some NPS structural analogues with similar spectra, it is necessary to select some low intensity but distinguishable peaks as characteristic absorption peaks. Only when all the characteristic absorption peaks are detected can the positive detection be concluded. According to this principle, characteristic absorption peaks of 168 regulated NPS were determined, and formed the IR method part of the industry standard Forensic sciences Examination methods for 168 new psychoactive substances including 2-FA in suspected drugs GC-MS, IR and LC. The rapid qualitative analysis of NPS by infrared spectroscopy based on a characteristic peak method will greatly improve the efficiency and reduce the cost of NPS qualitative identification analysis.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

In an article, author is Gong, Ningbo, once mentioned the application of 106261-49-8, Application In Synthesis of 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, molecular formula is C13H20Cl2N2O2, molecular weight is 307.22, MDL number is MFCD07772867, category is piperazines. Now introduce a scientific discovery about this category.

Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin-Piperazine Cocrystal

A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized. The solid form was prepared by liquid assisted grinding, slurry and crystallization methods. The cocrystal was characterized by powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and structure determined by single crystal X-ray diffraction, the hydrogen bonds formed into fish bone structure along the [010] direction and all the molecules packed into 3D layer structure along a axis. After formation of cocrystal, the solubility of diosgenin was improved, and the solubility value in 0.2% SDS solution was approximately 1.5 times as large as that of the parent material. Graphic

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Li, Zerui, once mentioned the application of 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, molecular weight is 114.1888, MDL number is MFCD00059912, category is piperazines. Now introduce a scientific discovery about this category, Category: piperazines.

Organic Amines as Targeting Stabilizer at the Polymer/Fullerene Interface for Polymer:PC61BM Solar Cells

Herein, it is demonstrated that a small amount (0.05% in weight ratio) of polyethyleneimine (PEI) can effectively suppress the burn-in degradation of both PTB7-Th:PC61BM and P3HT:PC61BM cells, similar to the piperazine derivatives, suggesting that organic amines can serve as universal stabilizer in polymer:PC61BM solar cells. Light-induced electron spin resonance (LESR) spectroscopy measurement shows a higher ESR signal intensity of PC61BM anions in 0.2% PEI-doped film than in 1% piperazine-doped film. Moreover, no piperazine is detected in a 10% (w/w) piperazine-doped film by gas chromatography-mass spectrometry (GS-MS). These results suggest that the residual piperazine in the blend film is very low, which can be understood by the high volatility of piperazine. Quantum calculations are performed on the intermolecular binding energy (E-B) between polymer (using model repeating units), PC61BM, and piperazine molecules. Results reveal that piperazine prefers to localize at the polymer:fullerene interface by complexing with PC61BM (in P3HT:PC61BM) or PTB7-Th (in PTB7-Th:PC61BM system), which indicates that the photo dimerization of PC61BM which causes the burn-in degradation of polymer:fullerene solar cells mainly happens at the donor/acceptor interface, and the organic amine serves as the targeting stabilizer at the interface.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, in an article , author is Howard, Zachary P., once mentioned of 5294-61-1, Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Selective Inhibition of Coxiella burnetii Replication by the Steroid Hormone Progesterone

Coxiella burnetii is a zoonotic bacterial obligate intracellular parasite and the cause of query (Q) fever. During natural infection of female animals, C. burnetii shows tropism for the placenta and is associated with late-term abortion, at which time the pathogen titer in placental tissue can exceed one billion bacteria per gram. During later stages of pregnancy, placental trophoblasts serve as the major source of progesterone, a steroid hormone known to affect the replication of some patho-gens. During infection of placenta-derived JEG-3 cells, C. burnetii showed sensitivity to progesterone but not the immediate precursor pregnenolone or estrogen, another major mammalian steroid hormone. Using host cell-free culture, progesterone was determined to have a direct inhibitory effect on C. burnetii replication. Synergy between the inhibitory effect of progesterone and the efflux pump inhibitors verapamil and 1-(1-naphthylmethyl)-piperazine is consistent with a role for efflux pumps in preventing progesterone-mediated inhibition of C. burnetii activity. The sensitivity of C. burnetii to progesterone, but not structurally related molecules, is consistent with the ability of progesterone to influence pathogen replication in progesterone producing tissues.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 5294-61-1, you can contact me at any time and look forward to more communication. Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, in an article , author is Yuan, Bochuan, once mentioned of 139755-85-4, Recommanded Product: 139755-85-4.

Piperazine ring formation by a single-module NRPS and cleavage by an alpha-KG-dependent nonheme iron dioxygenase in brasiliamide biosynthesis

Brasiliamides are a class of piperazine-containing alkaloids produced by Penicillium brasilianum with a range of pharmaceutical activities. The mechanism of brasiliamide biosynthesis, including piperazine ring formation and multiple tailoring modifications, still remains unclear. In this study, the biosynthetic gene cluster of brasiliamides, brs, was identified from the marine-derived fungal strain Penicillium brasilianum WZXY-M122-9. Deletion of a histone deacetylase-encoding gene using a CRISPR/Cas9 gene editing system led to the production of a new compound, namely brasiliamide I (1). The brs-encoded single-module nonribosomal peptide synthetase (NRPS) BrsA is involved in the formation of the piperazine skeleton of brasiliamides. Full-length BrsA protein (113.6 kDa) was purified, and reconstitution of enzymatic activity in vitro confirmed that BrsA stereoselectively accepts l-phenylalanine as the substrate. Multiple deletion of tailoring genes and analysis of purified proteins in vitro enabled us to propose a brasiliamide biosynthetic pathway. In the tailoring steps, an alpha-ketoglutarate (KG)-dependent nonheme iron dioxygenase, BrsJ, was identified to catalyze piperazine ring cleavage during biosynthesis of brasiliamide A (2).

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, molecular formula is C10H20N2O2, belongs to piperazines compound, is a common compound. In a patnet, author is Gohain, Moucham Borpatra, once mentioned the new application about 147081-29-6, Product Details of 147081-29-6.

Development of thin film nanocomposite membrane incorporated with mesoporous synthetic hectorite and MSH@UiO-66-NH2 nanoparticles for efficient targeted feeds separation, and antibacterial performance

Functionalized metal-organic frameworks (MOFs) and their composites are found one of the best material to develop the thin-film nanocomposite (TFN) membranes and concern water purification technologies with boosted water flux and targeted feeds rejection performance. MOFs with suitable functionalities are found more stable and efficient due to strong interfacial polymerization with free functional groups which consequently resulted in a thin selective nanocomposite layer on the surface of polysulfone flat sheet membranes. Similarly, mesoporous synthetic hectorite (MSH), due to negative surface charge acts as the best support material to avoid high agglomeration of positively charged MOF crystals. Additionally, surface hydroxyl functionalities with high dispersion capability in a polymer monomer solution makes MSH as a promising material for MOF support and development of novel membranes. Herein considering all these advantageous aspects of both material, we have established a novel approach for developing of TFN membranes by incorporating MSH, and composite of MSH and MOF (UiO-66-NH2) nanoparticles in piperazine (PIP) aqueous monomer solution, which were further interfacially polymerized with trimesoyl chloride (TMC) organic phase monomer. The developed nanoparticles (MSH and MSH@UiO-66-NH2) formulation were confirmed by ideal characterization techniques such as, PXRD, FTIR, TGA and SEM. Whereas, alteration impact of MSH and MSH@UiO-66-NH2 nanoparticles on prepared membranes were physicochemically evaluated with original TFC membrane by ATR-FTIR, FE-SEM, HR-TEM, AFM, XPS, TGA, zeta potential and contact angle analysing techniques. The efficacy performance of the developed TFN membranes were compared with thin-film composite (TFC) membrane and found that TFN membranes showed excellent water flux and rejection performances against different synthetic feed solutions including most common salts (i. e. NaCl, Na2SO4, CuSO4, MgSO4, MnSO4), toxic boron in the seawater and bulky humic substances. Interestingly upon incorporation of a small amount of (0.01%) MSH and MSH@UiO-66-NH2 nanoparticles into the developed membrane dramatically improved rejection performance against applied feed solutions in the trend of TFC < MSH-TFN < MSH@UiO-66-NH2-TFN. The highest rejection 94.42% for MgSO4 was obtained along with the flux 34.78 L/m(2).h at 1.5 MPa. Likewise, 69.56 L/m(2).h flux with 71.23% rejection for boron at pH 8 (close to sea water) at 1.5 MPa. Due to hydrophilic and notable antifouling nature of TFN membranes the tested membrane shows excellent humic acid permeate flux of 80.68 L/m(2).h and rejection of 98.96%. Besides, MSH@UiO-66-NH2-TFN membrane showed noteworthy antibacterial properties with efficient reduction in the bacterial colony growth. We believed that the present novel membrane modification approach has high potential in the development of high efficient water purification technologies in future. If you¡¯re interested in learning more about 147081-29-6. The above is the message from the blog manager. Product Details of 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is , belongs to piperazines compound. In a document, author is Beng, Timothy K., SDS of cas: 5625-37-6.

Modular synthesis and transition metal-free alkynylation/alkenylation of Castagnoli-Cushman-derivedN,O- andN,S-heterocyclic vinyl chlorides

A modular and functional group-tolerant protocol for the transition metal-free coupling of novelN,O- andN,S-heterocyclic vinyl chlorides with terminal acetylenes and styrenes has been developed, leading to the epimerization-free synthesis of fully carbofunctionalized dihydro-1,4-oxazines/thiazines. Bicyclic morpholines have also been prepared through the interrogation of newly synthesized cross-conjugated dienes in Diels-Alder reactions. The use of environmentally benign reaction media endows the current strategy with a practical advantage.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5625-37-6, in my other articles. SDS of cas: 5625-37-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics