Month: March 2021

In an article, author is Yu, Jinsong, once mentioned the application of 5308-25-8, SDS of cas: 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, molecular weight is 114.1888, MDL number is MFCD00059912, category is piperazines. Now introduce a scientific discovery about this category.

Mechanisms of Cd (II) binding to GMP and UMP: a combined conductometry, isothermal titration calorimetry and NMR study

In this research, conductometry was applied as a rapid method to screen functional ligands of cadmium ion-imprinted polymers for the first time. To better understand the binding mechanisms of Cd(II) to nucleoside monophosphates (NMPs), isothermal titration calorimetry (ITC) and nuclear magnetic resonance spectroscopy (NMR) experiments were carried out. First, the magnitude of conductivity change, Delta sigma, was found to be proportional to the ligand’s binding capacity to cadmium, and the Delta sigma(GMP) approximate to Delta sigma(dGMP) = 103.5 mu s center dot cm(-1). Second, the ITC experiments indicated that the coordination binding of Cd(II) and guanosine monophosphate (GMP) in 4-(2-hydroxyerhyl)piperazine-1-erhanesulfonic acid (HEPES)/boric acid buffers were demonstrated as different thermodynamic process: an exothermic process (Delta H = -1.446 kcal center dot mol(-1)) in HEPES, and an exothermic process (Delta H = – 1.495 kcal center dot mol(-1)) followed by an endothermic one (Delta H = 1.383 kcal mol(-1)) in boric acid. In contrast, the formation of the Cd(II)-uridine monophosphate (UMP) system was an endothermic process in both buffers. NMR experiments indicated that the shift Delta delta of the GMP’s proton signals were different, especially for H-1: 0.37 ppm in HEPES, and 0.03 ppm in boric acid. Referring to the results of ITC experiments, the major Cd(II) binding sites of GMP in HEPES buffer was the guanosine group, and phosphate group was another site in the boric acid buffer. By contrast, the major Cd(II) binding site of UMP was the phosphate group in both buffers. In general, investigating the functional ligand-cadmium binding mechanism has provided important theoretical and experimental guidance for the subsequent preparation of cadmium ion-imprinted materials.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2. In an article, author is Ramdane, Khaled Ait,once mentioned of 5308-25-8, Category: piperazines.

Crystal structure, characterization and chemical reactivity of novel piperazine derivative ligand for electrochemical recognition of nitrite anion

A novel piperazine derivative (3E,3E)-3,3-(((piperazine-1,4-diyl bis (ethane-2,1-diyl)) bis (azanediyl)) bis (ethan1-yl-1-ylidene)) bis (6-methyl-2H-pyran-2,4(3H)-dione) (2E-Peaemp) has been synthesized and characterized by ESI-MS, Single-crystal X-ray diffraction, NMR (H-1 NMR, C-13 NMR and 2D NMR), ATR-FTIR, UV-Visible and SEM. The theoretical study of chemical reactivity of 2E-Peaemp was investigated using DFT method. The oxidation-reduction processes and interaction between 2E-Peaemp and nitrite ions were studied using cyclic voltammetry technique. In addition, the detection of NO2- was investigated in 0.1 M PBS solution (pH = 7.0) using a carbon paste electrode modified with reduced graphene oxide-graphite carbon/2E-Peaemp system (rGO-GC/2E-Peaemp). XRD study showed that 2E-Peaemp crystallizes in a monoclinic system with P2(1)/c space group, and the results obtained from theoretical study well support the experimental results. According to DFT study, HOMO (Highest Occupied Molecular Orbitals)-LUMO (Lowest Unoccupied Molecular Orbitals) energy gap (E-gap) and other reactivity descriptors were calculated. The results showed that the ligand exhibits a high chemical reactivity and low kinetic stability. Finally, the cyclic voltammetry measurements showed significant current responses of rGO-GC/2E-Peaemp electrode towards NO2- in the concentration range of 0-4 mM with a low limit of detection (LOD = 0.83 mu M).Graphic abstract New ligand (2E-Peaemp: (3E,3 ‘ E)-3,3 ‘-(((piperazine-1,4-diyl bis (ethane-2,1-diyl)) bis (azanediyl)) bis (ethan1-yl-1-ylidene)) bis (6-methyl-2H-pyran-2,4(3H)-dione)) has been synthesized and characterized by XRD technique. The reactivity descriptors have been calculated by DFT. The ligand was used for electrochemical recognition of nitrite anion. The cyclic voltammetry showed that the modified electrode with 2E-Peaemp exhibits low detection limit towards NO2-.

Interested yet? Keep reading other articles of 5308-25-8, you can contact me at any time and look forward to more communication. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 5308-25-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, belongs to piperazines compound. In a article, author is Ooi, Zhe Lun, introduce new discover of the category.

Amine-based solvent for CO2 absorption and its impact on carbon steel corrosion: A perspective review

Carbon dioxide (CO2) is one of the commonly emitted gaseous by-products in industrial processes. While CO2 gas is the main cause to greenhouse effect, various CO2 capture technologies have been proposed and implemented to sequester the CO2 before the waste gases being released into the atmosphere. One of the mature technologies for CO2 absorption is by using amine-based solvents. In this regard, different single amine solvents or blended amine solvents have been proven for their capability to remove CO2. However, the dissolution and reaction of CO2 gas with the amine solvents turn the solution corrosive. Such phenomenon is undesired as it posts corrosion problem to the absorption column, which normally built of carbon steel material. Henceforth, understanding the behaviour of different amine-based solvents in absorbing CO2 and its subsequent impact on carbon steel corrosion is very significant. In this review article, we will outline some of the more commonly used solvents and their respective advantages and disadvantages, motivating further investigation into the corrosion tendency. Meanwhile, existing gaps in this research area are discussed for future investigation. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.

Electric Literature of 5308-25-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 5308-25-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Synthetic Route of 139755-85-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, SMILES is O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCC)N1, belongs to piperazines compound. In a article, author is Kamaal, Saima, introduce new discover of the category.

A Three-Dimensional Pentanuclear Co(II) Coordination Polymer: Structural Topology, Hirshfeld Surface Analysis and Magnetic Properties

A 3D pentanuclear coordination polymer of Co(II); {[Co-5(L2-)(4)(HL-)(2)(bpmp)(2) (H2O)(2)].(H2O)(5)}(n) (CP1) was synthesized by the self-assembly of semi-flexible 5-benzylamino-isophthalic acid (H2L) and N-donor auxiliary ligand 1,4-bis(4-pyridinylmethyl)piperazine (bpmp) using Co(NO3)(2) . 6H(2)O under hydrothermal condition. The CP1 has been structurally characterized by elemental analysis, TGA, Powder-XRD and IR spectroscopy which was further corroborated by single crystal X-ray studies. Structurally, it is a 3D pentanuclear cobalt cluster secondary building units (SBUs) which are formed by carboxylates oxygen of H2L and nitrogen of bpmp. The topological analysis revealed that CP1 possesses a 2-nodal 5,6-connected three-dimensional (3D) coordination framework with pcu net. Variable temperature magnetic measurements demonstrate that CP1 shows antiferromagnetic behavior.

Synthetic Route of 139755-85-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 139755-85-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Product Details of 5308-25-8, begins with the direct observation of nature¡ª in this case, of matter.5308-25-8, Name is 1-Ethylpiperazine, SMILES is CCN1CCNCC1, belongs to piperazines compound. In a document, author is Kong, Qing, introduce the new discover.

Fabrication of high performance TFN membrane containing NH2-SWCNTs via interfacial regulation

A high-flux thin film nanocomposite (TFN) nanofiltration (NF) membrane for low pressure operation (3.5 bar) was fabricated by blending purified amino-functionalized single-walled carbon nanotubes (NH2-SWCNTs) with piperazine (PIP) as aqueous phase monomers through interfacial polymerization (IP). The surface properties and structures of the polyamide (PA) active layer were suitably tailored by introducing different amounts of NH2-SWCNTs into the PA layer. It was found that the homogeneous incorporation of NH2-SWCNTs facilitated a more integral PA layer along with improved roughness, hydrophilicity, and surface charge of the modified membranes, which could be validated by membrane characterisation including SEM, AFM, ATR-FTIR, XPS, zeta potential and water contact angle measurements. Based on cross-flow NF tests, the optimized ultra-thin NH2-SWCNT-TFN membranes with 0.002 wt% of NH2-SWCNTs exhibited outstanding water permeability of up to 17.8 L m(-2)h(-1)bar(-1), 71.1% higher than that of the pristine membrane, along with high MgSO(4)rejection of 91.0% and Na(2)SO(4)rejection of 96.34%. Meanwhile, NH2-SWCNT-TFN membranes also showed excellent long-term stability and antifouling ability. This work demonstrates a facile strategy to fabricate a scalable, low-pressure and ultra-thin TFN membrane with excellent performance.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5308-25-8. Product Details of 5308-25-8.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, in an article , author is Nawaz, Hamid, once mentioned of 841-77-0, Formula: C17H20N2.

Structural chemistry and anticancer activity of new heteroleptic palladium(II) carbodithioates

Four new potent anticancer palladium(II) complexes containing PdClPS2 coordination sphere have been synthesized and characterized by different analytical techniques. Here, P is the donor atom from organophosphine (triphenylphosphine (1 and 3) and tris(p-chlorophenyl)phosphine (2 and 4)) and S 2 chelate is from carbodithioate (N,N’-dibenzyl-1-carbodithioate (1 and 2) and 4-(2hydroxyethyl)piperazine-1-carbodithioate (3 and 4)). All complexes exhibited distorted square planar geometry around Pd center owing to the chelate restriction of carbodithioate. The complexes are more potent anticancer (1-4) and antioxidant (3) agents than the standard drugs ((anticancer activity against HepG2: IC50 (mu M) = 23.39 (1) < 77.27 (3) < 82.62 (2) < 86.65 (4) 110 (doxorubicin) and (antioxidant activity against DPPH 65.6 (%) (3) and total antioxidant capacity expressed as equivalent of ascorbic acid (3) 51.4 mu g/mg, respectively)). Interestingly, the complexes demonstrated low lethal effects as determined by brine shrimp assay. The lethality sequence is opposite to that observed in anticancer (LD50 (ppm): 102.87 (1) 65.54 (3) > 62.50 (2) > 39.82 (4)) indicating high selectivity of 1 and 3 towards cancer cells. Anticancer activities were found to depend on the molecular stability and axial protection offered by organophosphine of the complexes. (c) 2020 Elsevier B.V. All rights reserved.

Interested yet? Read on for other articles about 841-77-0, you can contact me at any time and look forward to more communication. Formula: C17H20N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 841-77-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 841-77-0, Name is 1-Benzhydrylpiperazine, SMILES is N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCNCC1, belongs to piperazines compound. In a article, author is Corre, Michelle F., introduce new discover of the category.

Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H-3 and H(4 )receptors

Histamine acts through four different receptors (H1R-H4R), the H3R and H4R being the most explored in the last years as drug targets. The H3R is a potential target to treat narcolepsy, Parkinson’s disease, epilepsy, schizophrenia and several other CNS-related conditions, while H4R blockade leads to anti-inflammatory and immunomodulatory effects. Our group has been exploring the dihydrobenzofuranyl-piperazines (LINS01 series) as human H3R/H4R ligands as potential drug candidates. In the present study, a set of 12 compounds were synthesized from adequate (dihydro)benzofuran synthons through simple reactions with corresponding piperazines, giving moderate to high yields. Four compounds (1b, 1f, 1g and 1h) showed high hH(3)R affinity (pK(i) > 7), compound 1h being the most potent (pK(i) 8.4), and compound if showed the best efficiency (pKi 8.2, LE 0.53, LLE 5.85). BRET-based assays monitoring G alpha(i) activity indicated that the compounds are potent antagonists. Only one compound (2c, pK(i) 7.1) presented high affinity for hH(4)R. In contrast to what was observed for hH(3)R, it showed partial agonist activity. Docking experiments indicated that bulky substituents occupy a hydrophobic pocket in hH(3)R, while the N-allyl group forms favorable interactions with hydrophobic residues in the TM2, 3 and 7, increasing the selectivity towards hH(3)R. Additionally, the importance of the indole NH in the interaction with Glu5.46 from hH(4)R was confirmed by the modeling results, explaining the affinity and agonistic activity of compound 2c. The data reported in this work represent important findings for the rational design of future compounds for hH(3)R and hH(4)R.

Electric Literature of 841-77-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 841-77-0.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Murugesan, Arul, once mentioned the application of 109-01-3, Name is 1-Methylpiperazine, molecular formula is C5H12N2, molecular weight is 100.1622, MDL number is MFCD00005966, category is piperazines. Now introduce a scientific discovery about this category, COA of Formula: C5H12N2.

Synthesis, spectroscopic, DFT, HSA binding and docking studies of new 1,5-bis(4-chlorophenyl)-3-(2-(4-methylpiperazin-1-yl)quinolin-3yl)pentane-1,5-dione

1,5-Bis(4-chlorophenyl)-3-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)pentane-1,5-dione was synthesised and characterised using single-crystal X-ray Crystallography, FT-IR, H-1-NMR, C-13-NMR and UV-Visible spectroscopy. DFT calculations were performed at the B3LYP/6-311++G (d.p) level of theory in the gas phase. Frontier Molecular Orbitals (FMO) yielded HOMO-LUMO energy as: E-HOMO = -6.015 eV, E-LUMO = 2.525 eV and energy gap, similar to E-gap = 3.490 eV. Fukui Function Analysis (FFA) indicated the reactive sites for electrophilic, and nucleophilic attack. The molecule’s electrophilic addition site is 4-N in the piperazine group with a value of 0.020. The site for nucleophilic attack is both 13-C and 15-C in the quinoline group with values of 0.02 and 0.031 respectively. The biological activity was elucidated by molecular docking studies that gave a similar to G value for HSA binding of -26.44 kJ mol(-1) which is approximately similar to the experimental value obtained from emission spectral data of -32.15 kJ mol(-1). (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, belongs to piperazines compound. In a document, author is Orhan, Ozge Yuksel, introduce the new discover, HPLC of Formula: C11H17N3.

The development of reaction kinetics for CO2 absorption into novel solvent Frustrated Lewis (FLPs)

Frustrated Lewis Pairs (FLPs) comprising sterically hindered Lewis acids and bases were developed and kinetic parameters for the homogenous reaction between CO2 and FLP dissolved in bromobenzene were obtained by using the stopped-flow method for the first time in the scope of this work. As a sterically hindered Lewis acid chlorobis(pentafluorophenyl)borane, B(C6F5)(2)Cl and as a sterically hindered Lewis base tri-tert-butylphosphine, tBu(3)P were analyzed. Experiments were performed by varying FLP concentration in bromobenzene medium over the range of 0.02-0.035 M and for a temperature range of 298-313 K. Modified termolecular reaction mechanism was used to analyse the experimental kinetic data. Then, the relatively low reaction rate of FLP: bromobenzene system was enhanced significantly by blending constant amounts of promoters, such as amino ethyl piperazine (AEPZ), carbonic anhydrase (CA) and 1-ethyl-3-methyl imidazolium bis (trifluoromethyl sulfonyl) imide ([emim][Tf2N]). The intrinsic reaction rates of promoted solvents were measured in a stopped-flow technique over a temperature range of 293-323 K. The empirical power law reaction orders with respect to FLP concentration were found to be between 1.0 and 2.0 at various temperatures. Additionally, at these operating conditions, the promoting effects of AEPZ, CA, and [emim][Tf2N] results in a higher reaction rate and lower activation energy values.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 16153-81-4. HPLC of Formula: C11H17N3.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, SMILES is O=S(CCN1CCN(CCS(=O)(O)=O)CC1)(O)=O, belongs to piperazines compound. In a document, author is Taniguchi, Ikuo, introduce the new discover, Computed Properties of C8H18N2O6S2.

Piperazine-immobilized polymeric membranes for CO2 capture: mechanism of preferential CO2 permeation

Amines are incorporated into various membranes to improve their CO2 separation performance. With amine-containing polymeric membranes, gas transport properties are often enhanced under humidity, where CO2 migrates through the membranes in the form of bicarbonate ions. Piperazine (Pz) and its derivatives are known to catalyze the conversion of CO2 to bicarbonate ions and have been used in liquid amine scrubbing technology. Piperazines were immobilized in poly(vinyl alcohol) (PVA), and the resulting polymeric membranes showed high CO2 separation performance over H-2 and CH4. The gas transport properties were dependent on the chemical structure of the amines. In particular, 3-(1-piperazinyl)-1,2-propanediol (PzPD)-containing polymeric membranes gave excellent CO2 separation performance, and the CO2 permeability and CO2 selectivity over CH4 were 1060 Barrer and 370, respectively, at 50 degrees C and 90% relative humidity with a transmembrane CO2 pressure of 11 kPa. The interaction between PzPD and CO2 was quantitatively studied by inverse-gate decoupling C-13 NMR spectroscopy. CO2 interacted with the secondary amino group on the Pz ring to form a carbamate, which was readily hydrolyzed to produce bicarbonate ions. The hydroxyl group on the C2 carbon of PzPD facilitated the interaction between CO2 and the amine through hydrogen bonding, resulting in enhanced diffusivity of CO2 in the membranes.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5625-37-6 is helpful to your research. Computed Properties of C8H18N2O6S2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics