Month: March 2021

In an article, author is Jia, Zehui, once mentioned the application of 111974-74-4, SDS of cas: 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S, molecular weight is 368.3239, MDL number is MFCD08703302, category is piperazines. Now introduce a scientific discovery about this category.

Rapid degradation of ciprofloxacin over BiOCl: Insight into the molecular structure transformation and antibacterial activity elimination

Currently, the widespread usage of antibiotics brings great challenge to sustainable water environment due to the production of drug-resistant bacteria, the rapid and effective removal of antibiotics attracts more and more attention. Herein, a BiOCl microsphere prepared by a facile hydrolysis method via controlling the EG-H2O ratio was found to have unexpected photocatalytic activity for ciprofloxacin (CIP) removal. The photodegradation rate of CIP over optimal BiOCl-20 reached 92.9% in only 3 min of simulated sunlight irradiation, and the mineralization rate was 30.8% after 60 min reaction. The antibacterial tests of CIP solution under different irradiation minutes were evaluated using Escherichia coli (E. coli) as the model bacteria. The results indicated that CIP photodegradation intermediates had also certain antimicrobial potency, which could be eliminated almost completely after 3 min irradiation, although there still had some incompletely mineralized intermediates. In view of these results, the macroscopic degradation behavior of CIP over BiOCl-20 as well as the microscopic existence state and reaction behavior of the intermediates should be clarified. A ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed for determination of CIP and its intermediates. Ten primary intermediates were separated and identified, and their corresponding molecular structures were elucidated. Three main photodegradation pathways were deduced, and the correlation between molecular structure transformation and antibacterial activity of CIP was established. Because of the destruction of piperazine ring and defluorination of quinolone ring, the antibacterial activity of the treated CIP solution was weakened or even eliminated. Finally, a possible photodegradation mechanism was proposed, the OVs, O-center dot(2)-, h(+) and (OH)-O-center dot played significant roles in the CIP photodegradation. This work does have great perspective for BiOCl potential application in CIP wastewater treatment.

If you are interested in 111974-74-4, you can contact me at any time and look forward to more communication. SDS of cas: 111974-74-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 106261-49-8, Name is 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, SMILES is Cl.Cl.CN1CCN(CC1)CC2=CC=C(C(=O)O)C=C2, in an article , author is Kettenmann, Sebastian Doniz, once mentioned of 106261-49-8, Name: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Copper(II) Complexes with Tetradentate Piperazine-Based Ligands: DNA Cleavage and Cytotoxicity

Five-coordinate Cu(II) complexes, [Cu(L-n)X]ClO4/PF6, where L-n = piperazine ligands bearing two pyridyl arms and X = ClO4- for L-n = L-1 (1-ClO4), L-2 (2-ClO4), L-3 (3-ClO4), and L-6 (6-ClO4) as well as [Cu(L-n)Cl]PF6 for L-n = L-1 (1-Cl), L-4 (4-Cl), and L-5 (5-Cl) have been synthesized and characterized by spectroscopic techniques. The molecular structures of the last two complexes were determined by X-ray crystallography. In aqueous acetonitrile solutions, molar conductivity measurements and UV-VIS spectrophotometric titrations of the complexes revealed the hydrolysis of the complexes to [Cu(L-n)(H2O)](2+) species. The biological activity of the Cu(II) complexes with respect to DNA cleavage and cytotoxicity was investigated. At micromolar concentration within 2 h and pH 7.4, DNA cleavage rate decreased in the order: 1-Cl approximate to 1-ClO4 > 3-ClO4 >= 2-ClO4 with cleavage enhancements of up to 23 million. Complexes 4-Cl, 5-Cl, and 6-ClO4 were inactive. In order to elucidate the cleavage mechanism, the cleavage of bis(4-nitrophenyl)phosphate (BNPP) and reactive oxygen species (ROS) quenching studies were conducted. The mechanistic pathway of DNA cleavage depends on the ligand’s skeleton: while an oxidative pathway was preferable for 1-Cl/1-ClO4, DNA cleavage by 2-ClO4 and 3-ClO4 predominantly proceeds via a hydrolytic mechanism. Complexes 1-ClO4, 3-ClO4, and 5-Cl were found to be cytotoxic against A2780 cells (IC50 30-40 mu M). In fibroblasts, the IC50 value was much higher for 3-ClO4 with no toxic effect.

Interested yet? Read on for other articles about 106261-49-8, you can contact me at any time and look forward to more communication. Name: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C23H32N6O5S, belongs to piperazines compound. In a document, author is Villiou, Maria, introduce the new discover, Name: 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion

Hydrogels for wound management and tissue gluing applications have to adhere to tissues for a given time scale and then disappear, either by removal from the skin or by slow degradation for applications inside the body. Advanced wound management materials also envision the encapsulation of therapeutic drugs or cells to support the natural healing process. The design of hydrogels that can fulfill all of these properties with minimal chemical complexity, a stringent condition to favor transfer into a real medical device, is challenging. Herein, we present a hydrogel design with a moderate structural complexity that fulfills a number of relevant properties for wound dressing: it can form in situ and encapsulate cells, it can adhere to tissues, and it can be degraded on demand by light exposure under cytocompatible conditions. The hydrogels are based on starPEG macromers terminated with catechol groups as cross-linking units and contain intercalated photocleavable nitrobenzyl triazole groups. Hydrogels are formed under mild conditions (N-(2-hydroxyethyl)piperazine-N’-ethanesulfonic acid (HEPES) buffer with 9-18 mM sodium periodate as the oxidant) and are compatible with encapsulated cells. Upon light irradiation, the cleavage of the nitrobenzyl group mediates depolymerization, which enables the on-demand release of cells and debonding from tissues. The molecular design and obtained properties reported here are interesting for the development of advanced wound dressings and cell therapies and expand the range of functionality of current alternatives.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 139755-85-4. Name: 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O. In an article, author is Bitencourt, Monalisa,once mentioned of 5294-61-1, Recommanded Product: N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Buclizine crystal forms: First Structural Determinations, counter-ion stoichiometry, hydration, and physicochemical properties of pharmaceutical relevance

Buclizine (BCZ) is a chiral synthetic piperazine derivative which has antihistaminic, anti-muscarinic and antiemetic properties, and has been reintroduced as an appetite stimulant, especially for pediatric patients. Structural information about this drug, as well as other buclizine crystalline forms (solvates, salts and co-crystals) including the BCZ free-base (BCZ-FB), is non-existent. Here, we present for the first time the crystal structure of the monohydrochloride monohydrate salt of BCZ (BCZHCl center dot H2O), and of its anhydrous form, BCZHCl. Interestingly, BCZHCl center dot H2O was obtained by recrystallization from the raw material (BCZH(2)Cl(2)) in ethanol:water solution showing that BCZ anhydrous dihydrochloride salt changes easily to a monohydrochloride monohydrate salt modification, which raise concerns about formulation quality control. BCZHCl center dot H2O and BCZHCl crystallize in the orthorhombic space groups (Pna2(1) and Pca2(1)) belonging to the mm2 point group and are thus classified as non-centrosymmetric achiral structures (NA). Intuitively, we expect these salts to crystallize in a space group with a center of symmetry, since less than 5% of the known racemic compounds crystallize in the NA type. The crystal structures of BCZH(2)Cl(2) and BCZ-FB were not determined, but their existence was verified by other techniques (chloride ion analysis, PXRD, HPLC, FT-IR, DSC, TGA) and by comparison of the obtained results with those found for BCZHCl. Additionally, we have also performed an evaluation of the equilibrium solubility (at six different aqueous media) and the dissolution profile of the BCZHCl salt compared to the raw material and BCZ-FB. Different equilibrium solubility values were found comparing the three forms in acidic and neutral pH ranges and all of them were insoluble at pH > 7.0. Moreover, tablets prepared with BCZH(2)Cl(2), BCZHCl or BCZ-FB show significant differences in terms of dissolution profile.

Interested yet? Keep reading other articles of 5294-61-1, you can contact me at any time and look forward to more communication. Recommanded Product: N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 300543-56-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, belongs to piperazines compound. In a article, author is Gao, Peng, introduce new discover of the category.

High-Flux Fine Hollow Fiber Nanofiltration Membranes for the Purification of Drinking Water

High-flux fine hollow fiber nanofiltration (HFNF) membranes were prepared by interfacial polymerization (IP) using polysulfone (PSF) ultrafiltration (UF) membranes with an outer diameter of 425 mu m as the substrate for the treatment of drinking water. Trimesoyl chloride (TMC) was selected as the organic phase monomer, while poly(vinyl alcohol) (PVA) was added into piperazine (PIP) aqueous phase solution to reduce the surface defects and to enhance the separation performance of the NF membrane. The as-prepared fine HFNF membranes had a large packing density and effective area. The optimal preparation conditions of the fine HFNF membrane were determined by orthogonal experiments in which the flux of the membrane reached 34.2 +/- 1.5 L.m(-2).h(-1).bar(-1), while its salt rejection sequence was as follows: Na2SO4 (97.6 +/- 1.5%) > MgSO4 (96.1 +/- 1.8%) > MgCl2 (83.5 +/- 2.1%) > NaCl (27.9 +/- 2.6%). During the long-term stability test for 132 h, the membrane retained a high flux (>23.7 +/- 1.5 L.m(-2).h(-1).bar(-1)) and high Na2SO4 rejection (>97.2 +/- 1.1%). Additionally, it exhibited huge potential for application in drinking water purification in which the as-prepared NF membrane exhibited excellent antifouling performance for bovine serum albumin (BSA).

Electric Literature of 300543-56-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 300543-56-0 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, SMILES is CN1CCN(C2=CC=C(Br)C=C2)CC1, belongs to piperazines compound. In a document, author is Manasa, Kesari Lakshmi, introduce the new discover, Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Design and synthesis of beta-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability

A series of new beta-carboline linked aryl sulfonyl piperazine congeners have been synthesized by coupling various beta-carboline acids with substituted aryl sulfonyl piperazines. Evaluation of their anticancer activity against a panel of human cancer cell lines such as colon (HT-29), breast (MDA-MB-231), bone osteosarcoma (MG-63), brain (U87 MG), prostate (PC- 3) and normal monkey kidney (Vero) cell line has been done. Among the series, compound 8ec and 8ed has shown most potent cytotoxicity with an IC50 values of 2.80 +/- 0.10 mu M and 0.59 +/- 0.28 mu M respectively against MG-63 cell line and also potent on other cell lines tested. Compounds 8ec and 8ed was found to inhibit Topo II that is confirmed by specific Topo II inhibition assay. DNA binding studies, cell cycle analysis, Annexin V study indicate that these compounds has potential anticancer activity. Molecular docking studies for compound 8ec and 8ed are incorporated to understand the nature of interaction with topoisomerase IIa and dsDNA.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 130307-08-3 is helpful to your research. Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, HPLC of Formula: C5H12N2, begins with the direct observation of nature¡ª in this case, of matter.109-01-3, Name is 1-Methylpiperazine, SMILES is CN1CCNCC1, belongs to piperazines compound. In a document, author is Mu, Tong, introduce the new discover.

Three-channel capillary nanofiltration membrane with quaternary ammonium incorporated for efficient heavy metals removal

High-performance nanofiltration (NF) membranes have profound implications for water purification. Here, we reported a novelty polyamide NF membrane through introducing bis (2-hydroxyethyl) dimethyl-ammonium chloride (BHDA) in interfacial polymerization (IP) process on three-channel substrate membrane. This new monomer bearing abundant quaternary ammonium (N+) and hydroxyl could participate in the reaction between piperazine (PIP) and trimesoyl chloride (TMC). Then, not only was positive charge introduced into the NF membrane, but the hydrophilic of the resultant NF membrane was also significantly improved. Thus, the as-prepared PIP/BHDA-TMC (MPQ) membrane exhibited enhanced pure water flux (12.9 L.m(-2).h(-1).bar(-1)) which is 2.4 times as high as that of the PIP-TMC (MP) membrane, coupled with the salt rejection sequence as MgSO4 (93.46%) > Na2SO4 (91.61%) > MgCl2 (88.15%) > NaCl (22.03%). Meanwhile, MPQ exhibited a promising separation performance to various heavy metal salts (96.43% CuSO4, 96.16% ZnSO4, 91.69% Cu(NO3)(2), 89.69% ZnCl2, 88.37% Pb(NO3)(2)). The stability of MPQ was tested with simulated wastewater, and the results illustrated that it has a potential applicability for heavy metals removal.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 109-01-3. HPLC of Formula: C5H12N2.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3. In an article, author is Qiu, Xiang,once mentioned of 16153-81-4.

Design, synthesis and anti-inflammatory study of novel N-heterocyclic substituted Aloe-emodin derivatives

A novel series of Aloe-emodin derivatives containing N-heterocyclic moieties was designed and synthesized. The structure-activity relationship studies (SARs) indicated that the replacement of hydroxyethyl and benzhydryl piperazine groups could improve efficacy. Compounds12rand14a-14cexhibited a higher inhibitory effect on LPS-induced nitric oxide (NO) production in RAW264.7 macrophages than Aloe-emodin did. Among them,12rshowed the most potent inhibition with an IC(50)value of 5.66 +/- 0.47 mu M. Further toxicity and pharmacokinetic studies were carried out and12rwas found to be the most active structure with low toxicity risk and good metabolic properties. It could also decrease the levels of IL-1 beta, TNF-alpha, PGE(2)and inhibit the activation of nuclear factor-kappa B signalling pathway. Importantly,12rshowed oral bioavailability of up to 55.16% and attenuated the inflammatory symptoms in an ulcerative colitis mouse model in vivo. These results indicate that12ris suitable for development as an anti-inflammatory agent.

If you¡¯re interested in learning more about 16153-81-4. The above is the message from the blog manager. Quality Control of 4-(4-Methylpiperazin-1-yl)phenylamine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Reference of 147081-29-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Gupta, Anoop K., introduce new discover of the category.

A Three-Dimensional Cu(II)-MOF with Lewis acid-base dual functional sites for Chemical Fixation of CO2 via Cyclic Carbonate Synthesis

A 3D porous Cu(II)-MOF (1), having Lewis acid-base dual-functional sites, has been utilized, whose frameworks have two types of 1D channels decorated with both axially water-bound metal sites and weak base, i.e., tertiary amine groups in the crystallographic c-axis. Upon activation under a high vacuum at 120 degrees C, the axial water molecule is removed and affords a solvent-free and unsaturated Lewis acidic Cu(II) containing framework (1′). The piperazine functionalities from the linkers enhance the selective adsorption of CO2 which, in turn, facilitate the further interaction with the open Cu(II) metal centres, leading to catalytic chemical fixation of CO2 into five-membered cyclic carbonates, in the presence of epoxides and co-catalyst TBAB, under mild and solvent-free reaction conditions. The significance of dual functionalization and the synergy with TBAB on adeptly catalyzed CO2 fixation are explored using several epoxides, and substantial conversion is achieved. Moreover, the catalyst 1′ displays satisfactory stability and easy recyclability for five consecutive cycles without any appreciable loss in its catalytic activity. The results are compared with various MOFs based catalysts at the closest reaction conditions and, based on literature and experimental inferences, a possible mechanism of chemical fixation of CO2 with epoxide catalyzed by 1′ has been proposed.

Reference of 147081-29-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 111974-74-4, 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S, belongs to piperazines compound. In a document, author is Zhang, Li, introduce the new discover.

Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents

A total of 26 compounds based on osthole skeleton were designed, synthesized. Their cytoprotective abilities of antioxidation, anti-inflammation and A beta(42)(Amyloid beta-protein 42)-induced neurotoxicity were evaluated by MTT assays. Mechanism of the action of selected compounds were investigated by molecular docking. AlogP, logS and blood-brain barrier (BBB) permeability of all these compounds were simulated by admetSAR. Most of the compounds showed better antioxidative and anti-inflammatory activities compared with osthole, especially OST7 and OST17. The compound OST7 showed relative high activity in neuroprotection against H2O2 (45.7 +/- 5.5%), oxygen glucose deprivation (64.6 +/- 4.8%) and A beta(42) (61.4 +/- 5.2%) at a low concentration of 10 mu M. EC50 of selected compounds were measured in both H2O2 and OGD induced cytotoxicity models. Moreover, NO inhibiting ability of OST17(50.4 +/- 7.1%) already surpassed the positive drug indomethacin. The structure activity relationship study indicated that introduction of piperazine group, tetrahydropyrrole group and aromatic amine group might be beneficial for enhancement of osthole neuroprotective properties. Molecular docking explained that the reason OST7 exhibited relatively stronger neuroprotection against A beta because of the greater area of interactions between molecule and target protein. OST7 and OST17 both provided novel methods to investigate osthole as anti-AD drugs.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 111974-74-4. Product Details of 111974-74-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics