Month: March 2021

Synthetic Route of 111974-74-4, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, SMILES is [H]Cl.[H]Cl.C12=CC=CC=C1N=C(N3CCNCC3)C4=CC=CC=C4S2, belongs to piperazines compound. In a article, author is Rodriguez-Lavado, Julio, introduce new discover of the category.

Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer’s disease

During the last decade, the one drug-one target strategy has resulted to be inefficient in facing diseases with complex ethiology like Alzheimer’s disease and many others. In this context, the multitarget paradigm has emerged as a promising strategy. Based on this consideration, we aim to develop novel molecules as promiscuous ligands acting in two or more targets at the same time. For such purpose, a new series of indolylpropyl-piperazinyl oxoethyl-benzamido piperazines were synthesized and evaluated as multitarget-directed drugs for the serotonin transporter (SERT) and acetylcholinesterase (AChE). The ability to decrease beta-amyloid levels as well as cell toxicity of all compounds were also measured. In vitro results showed that at least four compounds displayed promising activity against SERT and AChE. Compounds 18 and 19 (IC50 = 3.4 and 3.6 mu M respectively) exhibited AChE inhibition profile in the same order of magnitude as donepezil (DPZ, IC50 = 2.17 mu M), also displaying nanomolar affinity in SERT. Moreover, compounds 17 and 24 displayed high SERT affinities (IC50 = 9.2 and 1.9 nM respectively) similar to the antidepressant citalopram, and significant micromolar AChE activity at the same time. All the bioactive compounds showed a low toxicity profile in the range of concentrations studied. Molecular docking allowed us to rationalize the binding mode of the synthesized compounds in both targets. In addition, we also show that compounds 11 and 25 exhibit significant beta-amyloid lowering activity in a cell-based assay, 11 (50% inhibition, 10 mu M) and 25 (35% inhibition, 10 mu M). These results suggest that indolylpropyl benzamidopiperazines based compounds constitute promising leads for a multitargeted approach for Alzheimers disease. (C) 2020 Elsevier Masson SAS. All rights reserved.

Synthetic Route of 111974-74-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 111974-74-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, SMILES is O=C(NC1=C(C)C=CC=C1C)CN2CCNCC2, belongs to piperazines compound. In a document, author is El Abbouchi, Abdelmoula, introduce the new discover, Computed Properties of C14H21N3O.

Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents

A series of ethacrynic acid (2-[2,3-dichloro-4-(2- methylidenebutanoyephenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding 6a and 6c, showed anti-proliferative activity with IC50, in the micromolar range (less than 4 uM). Three derivatives 6b, 7 b and 7 e were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRCS as a normal cell line. These compounds displayed IC50 values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker’s best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5294-61-1 is helpful to your research. Computed Properties of C14H21N3O.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 130307-08-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, SMILES is CN1CCN(C2=CC=C(Br)C=C2)CC1, belongs to piperazines compound. In a article, author is Hosseini, Mahdiyeh-Sadat, introduce new discover of the category.

Fabrication of new magnetite based sulfonic-phosphotungstic dual-acid catalyst for catalytic acetalization of benzaldehyde with ethylene glycol

A new sulfonic-phosphotungstic dual-acid hybrid catalyst based on silica coated magnetite nanoparticles (SCMNPs) containing two types of Bronsted acidic sites i.e. sulfonic acid (-SO3H) and phosphotungstic acid (HPW) groups, was prepared with chemical and electrostatic interactions of these acidic functional moieties with piperazine-grafted propylsilyl spacer groups. Physicochemical techniques including FT-IR spectroscopy, elemental analysis and inductively coupled plasma-optical emission spectroscopy (ICP-OES), vibrating sample magnetometry (VSM), X-ray diffraction (XRD), energy dispersive X-ray (EDX) analysis, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) were used to characterize the prepared solid acid catalyst. Acetalization reaction between benzaldehyde and ethylene glycol was done to investigate the catalytic activity of prepared catalyst and 97% conversion toward acetal production was reached in short reaction time. The lower conversion was also achieved for the same catalyst without any HPW species, demonstrated the positive role of the second acidic sites on progression of this reaction. In addition, this easily separable solid acid catalyst reused for four runs with no observable loss in benzaldehyde conversion.

Electric Literature of 130307-08-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 130307-08-3 is helpful to your research.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Category: piperazines, 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a document, author is Behroozi, Amir Hossein, introduce the new discover.

CO2 Reactive Absorption into an Aqueous Blended MDEA and TMS Solution: Experimental and Modeling

In this research, the significant environmental process of CO2 capture is investigated into an aqueous blended MDEA + TMS solution using a stirrer reactor experimentally and numerically. The experiments were designed based on the response surface methodology (RSM) under operating conditions of a pressure range of 2-8 bar, a temperature range of 20-70 degrees C, MDEA, and TMS concentration range of 10-20 wt%. The results indicated that by enhancing the initial pressure from 3.5 to 8 bar, the equilibrium CO2 loading increases by 17.8%. Based on RSM and central composite design method, the maximum values of CO2 loading and absorption percentages were 0.308% and 72.73%, respectively, at appropriate conditions of the temperature of 32.5 degrees C, the pressure of 3.5 bar, and MDEA and TMS concentrations of 12.5 wt%. A new relation for CO2 loading was correlated with a correlation coefficient of 0.994, as a function of studied independent variables.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16153-81-4 is helpful to your research. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 111974-74-4, Name is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride, molecular formula is C17H19Cl2N3S, belongs to piperazines compound, is a common compound. In a patnet, author is Shintani, Takuji, once mentioned the new application about 111974-74-4, Recommanded Product: 111974-74-4.

Preparation of monoamine-incorporated polyamide nanofiltration membranes by interfacial polymerization for efficient separation of divalent anions from divalent cations

For the purpose of efficient separation of sulfate ions from magnesium ions, novel negatively-charged nanofiltration membranes were developed by incorporating the monoamines 4-aminobenozic acid, aniline-2,5-disulfonic acid monosodium salt, and iminodiacetic acid (IDA) during interfacial polymerization of piperazine (PIP) and trimesoyl chloride. PIP-amide membranes without these monomers tended to reject magnesium ions as well as sulfate ions. In contrast, incorporation of the monoamines resulted in large molecular weight cut-offs and large negative charge densities thanks to carboxyl or sulfo terminal groups of the monoamines, which enabled preferential permeation of magnesium ions while maintaining high rejection of sulfate ions. In particular, the IDA-incorporated nanofiltration membrane with an IDA to PIP + IDA mass ratio of 0.40 showed high rejection of sulfate ions with low rejection of magnesium ions even when the concentration of sodium chloride was much higher than that of magnesium sulfate. This result indicates the feasibility of the developed membrane for magnesium recovery from desalinated seawater in the electrodialysis process for table salt production.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 111974-74-4. The above is the message from the blog manager. Recommanded Product: 111974-74-4.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mazari, Shaukat Ali, once mentioned the application of 139755-85-4, Name is 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C23H32N6O5S, molecular weight is 504.6024, MDL number is MFCD00908400, category is piperazines. Now introduce a scientific discovery about this category, Safety of 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Thermal degradation kinetics of morpholine for carbon dioxide capture

Deterioration of amines under process operating conditions for sour gas treatment is a severe problem. New amines are being investigated to replace conventional amines which face operational, economic and environmental challenges. Morpholine (MOR) is an understudied amine for carbon dioxide (CO2) capture which comes with good CO2 capture characteristics like CO2 absorption rate, CO2 solubility etc. This study investigates the stability of aqueous morpholine under stripper conditions. Effect of CO2 loading and temperature have been investigated on the degradation kinetics of MOR. CO2 loading is varied from 0 to 0.48 mol CO2/mol alkalinity and temperatures is varied 135-190 degrees C. Thermal degradation experiments were conducted using 316 stainless steel cylinders, closed with Swagelok (R) endcaps. The degraded samples were analyzed by using Gas Chromatography-Mass Spectrometry (GC-MS), Gas Chromatography-Flame Ionization Detector (GC-FID) and Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (LC-QToE-MS) for morpholine concentration and identification of degradation products. Morpholine demonstrated higher stability up to 150 degrees C. However, higher degradation rate is found at temperatures 175 degrees C and above. Degradation rate increases with CO2 loading. Identified degradation products are tabulated in the text and reaction mechanisms for formation of some of the key degradation products are also provided. A kinetic model for the rate of degradation of morpholine is proposed, which shows a decent agreement with experimental data. Comparison shows that morpholine is thermally more stable compared to monoethanolamine (MEA), diethanolamine (DEA), methyldiethanolamine (MDEA) and piperazine (PZ).

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 139755-85-4, Safety of 5-(2-Ethoxy-5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5625-37-6, Name is 2,2′-(Piperazine-1,4-diyl)diethanesulfonic acid, molecular formula is C8H18N2O6S2. In an article, author is Abbasi, Muhammad Athar,once mentioned of 5625-37-6, Product Details of 5625-37-6.

Synthesis of some N-sulfonated derivatives of 1-[(E)-3-phenyl-2-propenyl]piperazine as suitable antibacterial agents

In the planned research work, the nucleophilic substitution reaction of 1-[(E)-3-phenyl-2-propenyl]piperazine (1) was carried out with different sulfonyl chlorides (2a-g) at pH 9-10 to synthesize its different N-sulfonated derivatives (3a-g). The structures of the synthesized compounds were characterized by their proton-nuclear magnetic resonance (H-1-NMR), carbon-nuclear magnetic resonance (C-13-NMR) and Infra Red (IR) spectral data, along with CHN analysis. The inhibition potential of the synthesized molecules was ascertained against two bacterial pathogenic strains i.e. Bacillus subtilis and Escherichia coli. It was inferred from the results that some of the compounds were very suitable inhibitors of these bacterial strains. Moreover, their cytotoxicity was also profiled and it was outcome that most of these molecules possessed moderate cytotoxicity.

Interested yet? Keep reading other articles of 5625-37-6, you can contact me at any time and look forward to more communication. Product Details of 5625-37-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 130307-08-3, Name is 1-(4-Bromophenyl)-4-methylpiperazine, molecular formula is C11H15BrN2. In an article, author is Li, Si,once mentioned of 130307-08-3, Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Photocatalytic transformation fate and toxicity of ciprofloxacin related to dissociation species: Experimental and theoretical evidences

Chemical speciation of ionizable antibiotics greatly affects its photochemical kinetics and mechanisms; however, the mechanistic impact of chemical speciation is not well understood. For the first time, the impact of different dissociation species (cationic, zwitterionic and anionic forms) of ciprofloxacin (CIP) on its photocatalytic transformation fate was systematically studied in a UVA/LED/TiO2 system. The dissociation forms of CIP at different pH affected the photocatalytic degradation kinetics, transformation products (TPs) formation as well as degradation pathways. Zwitterionic form of CIP exhibited the highest degradation rate constant (0.2217 +/- 0.0179 min(-1)), removal efficiency of total organic carbon (TOC) and release of fluoride ion (F-). Time-dependent evolution profiles on TPs revealed that the cationic and anionic forms of CIP mainly underwent piperazine ring dealkylation, while zwitterionic CIP primarily proceeded through defluorination and piperazine ring oxidation. Moreover, density functional theory (DFT) calculation based on Fukui index well interpreted the active sites of different CIP species. Potential energy surface (PES) analysis further elucidated the reaction transition state (TS) evolution and energy barrier (Lambda E-b) for CIP with different dissociation species after radical attack. This study provides deep insights into degradation mechanisms of emerging organic contaminants in advanced oxidation processes associated to their chemical speciation. (c) 2020 Elsevier Ltd. All rights reserved.

Interested yet? Keep reading other articles of 130307-08-3, you can contact me at any time and look forward to more communication. Name: 1-(4-Bromophenyl)-4-methylpiperazine.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Category: piperazines, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2. In an article, author is Bhardwaj, Rajesh,once mentioned of 5308-25-8.

Inactivation-mimicking block of the epithelial calcium channel TRPV6

Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifactorial diseases, including cancers. Here, we study the molecular mechanism of selective nanomolar-affinity TRPV6 inhibition by (4-phenylcyclohexyl)piperazine derivatives (PCHPDs). We use x-ray crystallography and cryo-electron microscopy to solve the inhibitor-bound structures of TRPV6 and identify two types of inhibitor binding sites in the transmembrane region: (i) modulatory sites between the S1-S4 and pore domains normally occupied by lipids and (ii) the main site in the ion channel pore. Our structural data combined with mutagenesis, functional and computational approaches suggest that PCHPDs plug the open pore of TRPV6 and convert the channel into a nonconducting state, mimicking the action of calmodulin, which causes inactivation of TRPV6 channels under physiological conditions. This mechanism of inhibition explains the high selectivity and potency of PCHPDs and opens up unexplored avenues for the design of future-generation biomimetic drugs.

If you¡¯re interested in learning more about 5308-25-8. The above is the message from the blog manager. Category: piperazines.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics

Electric Literature of 147081-29-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 147081-29-6, Name is (S)-tert-Butyl 3-methylpiperazine-1-carboxylate, SMILES is O=C(N1C[C@H](C)NCC1)OC(C)(C)C, belongs to piperazines compound. In a article, author is Haruna, Kabiru, introduce new discover of the category.

N,N ‘-Bis-(2-aminoethyl)piperazine functionalized graphene oxide (NAEP-GO) as an effective green corrosion inhibitor for simulated acidizing environment

In this work we evaluated the corrosion inhibition efficacy of N,N’-Bis-(2-aminoethyl)piperazine functionalized graphene oxide (NAEP-GO) against carbon steel in 15% HCl which simulate oil well acidizing environment by weight loss (at ambient and higher temperatures) and electrochemical measurement experiments. The GO was synthesized using waste graphite, after which N,N’ -Bis-(2-aminoethyl)piperazine was grafted onto the GO. Both the GO and NAEP-GO were characterized by FTIR, Raman and TEM techniques. The effect of concentration, temperature and time on the performance of the inhibitor was investigated in this study. The inhibitor efficiency was observed to increase with concentration and a maximum inhibition efficiency of 87% was observed for 25 ppm NAEP-GO at room temperature. The inhibitor exhibited excellent performance at the studied temperatures, however the performance decreases with increase in temperature. The inhibitor showed excellent efficiency of over 80% for all the studied immersion time. The PDP measurement revealed the NAEP-GO to acts predominantly as a cathodic-type inhibitor. The studied compound was observed to obey the Langmuir adsorption isotherm. SEM/EDS, AFM surface morphology and FT-IR analyses of the corrosion product after 24 h’ immersion in the NAEP-GO inhibited solution provide evidence of adsorption of NAEP-GO molecules on the steel surface to form the protective NAEP-GO film that blocked the steel surface from the aggressive acid attack. This study is of importance in solving two main environmental problems, corrosion and the problem of waste disposal as GO was prepared from waste graphite.

Electric Literature of 147081-29-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 147081-29-6.

Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics