Synthetic Route of 16153-81-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 16153-81-4, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, SMILES is NC1=CC=C(N2CCN(C)CC2)C=C1, belongs to piperazines compound. In a article, author is Muresan-Pop, M., introduce new discover of the category.
Structural characterization of 5-fluorouracil & piperazine new solid forms and evaluation of their antitumor activity
A salt (FP-S) and two co-crystals (FP-C1 and FP-C2) of fluorouracil (FU) with piperazine (PZ) were investigated in terms of bioavailability and their effect on endothelial cells. From structural point of view, the best stability was observed for FP-C2 sample obtained by storage of FP-C1 sample under extreme conditions of temperature and humidity. This result was explained by the strong intermolecular interactions between 5-fluorouracil, piperazine and water, as denoted by the crystallographic analysis of FP-C2 form. Dissolution measurements in water indicate that the most soluble form is the salt, with a dissolution rate about 3 times greater than for the fluorouracil pure compound, while the solubility for co-crystals decreases compared to FU. Toxicity and antitumoral effect of the synthesized compounds were checked on three different cell lines: normal cells (HUVEC endothelial cells) and tumor cells (DLD-1 and HT29, both colorectal adenocarcinoma) and cytotoxicity by the MTT assay and cell proliferation assay. It has been found that the FP-C1 exerts a selective cytotoxic effect on HT29 cells and FP-C2 on DLD-1 cells in contrast to normal endothelial cell line resistance. For FU and FP-S salt, the effect on normal and tumoral cells is similar. The comparative study of the three fluorouracil forms shows that the best antitumor selective response was obtained for the co-crystal forms. (C) 2020 Elsevier B.V. All rights reserved.
Synthetic Route of 16153-81-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 16153-81-4 is helpful to your research.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics