Chemistry is an experimental science, Quality Control of 1-Benzhydrylpiperazine, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 841-77-0, Name is 1-Benzhydrylpiperazine, molecular formula is C17H20N2, belongs to piperazines compound. In a document, author is Watanabe, Hitoshi.
Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e] [1,4]diazepines with clozapine-like receptor occupancy at dopamine D-1/D-2 receptor
Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered (S)-3 as Clozapine-like dopamine D-2/D-1 receptor selectivity and improved reactive metabolites formation profile by the modification of piperazine moiety in Clozapine. The optimization of (S)-3 gave compound 5 to be best compound (approximately 10-fold stronger affinity for D-2/D-1 receptor and similar D-2/D-1 selectivity ratio with Clozapine). Clozapine-like D-2/D-1 receptor occupancy profile was proved by in vivo evaluation. In addition, the reactive metabolites derived agranulocytosis risk of compound 5 was considered to be lower than Clozapine. The pharmacology detail of compound 5 is being investigated to develop it for TRS treatment.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 841-77-0. Quality Control of 1-Benzhydrylpiperazine.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics