Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5308-25-8, Name is 1-Ethylpiperazine, molecular formula is C6H14N2, belongs to piperazines compound. In a document, author is Sanad, Sherif M. H., introduce the new discover, Category: piperazines.
Piperazine-mediated tandem synthesis of bis(thieno[2,3-b]pyridines): Versatile precursors for related fused [1,2,4]triazolo[4,3-a]pyrimidines
In this study, we discuss the utility of bis(cyanoacetamides) as versatile precursors to the piperazine-mediated synthesis of a wide spectrum of bis(thieno[2,3-b]pyridine) derivatives, linked to aliphatic spacers via thioethers. The proposed tandem protocol involved the reaction of bis(cyanoacetamides) with two equivalents of the appropriate cinnamonitriles in dioxane in the presence of six equivalents of piperazine at reflux for 4 hours. Then, two equivalents of the appropriate halogen-containing reagents were added and the reaction was heated at reflux for further 3 hours. The bis(thieno[2,3-b]pyridines) were taken as a key intermediates to new bis(4-oxopyrido[3 ‘,2 ‘:4,5]thieno[3,2-d]pyrimidines). The above derivatives were reacted with the appropriate hydrazonyl chloride derivatives in dioxane in the presence of triethylamine to yield the corresponding bis([1,2,4]triazoles) with a related fused pyridothienopyrimidine moiety. The new structures were elucidated by IR, NMR spectral data, as well as elemental analyses.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 5308-25-8. Category: piperazines.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics