In an article, author is Narczyk, Aleksandra, once mentioned the application of 300543-56-0, Recommanded Product: (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, molecular formula is C17H19ClN2, molecular weight is 286.8, MDL number is MFCD11519277, category is piperazines. Now introduce a scientific discovery about this category.
An entry to non-racemic beta-tertiary-beta-amino alcohols, building blocks for the synthesis of aziridine, piperazine, and morpholine scaffolds
A method for the preparation of enantiopure beta-tert-amino alcohols bearing a tetrasubstitutedC-stereocenter, as well as their conversion into selected medicinally privileged heterocyclic systems (morpholines, aziridines, piperazines) is reported. These compounds were obtained through enantiospecific sigmatropic rearrangement of allyl carbamates as a key step. The latter were prepared from the corresponding beta,beta ‘-dialkyl-substituted non-racemic allyl alcohols. In addition, an asymmetric synthesis of such highly substituted allylic alcoholsviaeither enantioselective 1,2-reduction of enones, enzymatic kinetic resolution, or a functionalization of chiral propargyl alcohols, with discussion of scope and limitations of each method is reported.
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics