5294-61-1, Name is N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide, molecular formula is C14H21N3O, belongs to piperazines compound, is a common compound. In a patnet, author is Chamakuri, Srinivas, once mentioned the new application about 5294-61-1, Application In Synthesis of N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide.
Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines
A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from alpha-amino acids, within four steps chiral 2-substituted piperazines are obtained. The key transformation involves an aza-Michael addition between an orthogonally bis-protected chiral 1,2-diamine and the in situ generated vinyl diphenyl sulfonium salt derived from 2-bromoethyl-diphenylsulfonium triflate. Further validation using different protecting groups as well as synthesis on multigram scale was performed. The method was also applied to the construction of chiral 1,4-diazepanes and 1,4-diazocanes. Additionally, the method was utilized in a formal synthesis of chiral mirtazapine.
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics