In an article, author is Murugesh, V, once mentioned the application of 16153-81-4, Recommanded Product: 4-(4-Methylpiperazin-1-yl)phenylamine, Name is 4-(4-Methylpiperazin-1-yl)phenylamine, molecular formula is C11H17N3, molecular weight is 191.27, MDL number is MFCD00172703, category is piperazines. Now introduce a scientific discovery about this category.
Ruthenium Catalyzed Regioselective beta-C(sp(3))-H Functionalization of N-Alkyl-N ‘-p-nitrophenyl Substituted Piperazines using Aldehydes as Alkylating Agents
Herein, we disclose a ruthenium-catalyzed regioselective beta-C(sp(3))-H bond functionalization on the piperazine core using aldehydes as alkylating agents. The present transformation appears to go through the dehydrogenation of the piperazine to propagate to enamine in situ, followed by nucleophilic addition to the aldehyde and hydrogenation to result in the regioselective beta-C(sp(3))-H alkylation. A variety of aromatic, heteroaromatic, aliphatic aldehydes were employed for the C-3 alkylation of N-alkyl-N ‘-p-nitrophenyl substituted piperazines.
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Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics