Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.300543-56-0, Name is (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine, SMILES is ClC1=CC=C([C@H](N2CCNCC2)C3=CC=CC=C3)C=C1, belongs to piperazines compound. In a document, author is Abbasi, M. A., introduce the new discover, Safety of (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine.
Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors
Four benzamide derivatives (5a, 5b,8a, 8b) bearing heterocyclic furan and piperazine ring have been synthesized and evaluated for enzyme inhibition and hemolytic activity. Initial 4-(chloromethyl)benzoyl chloride (1) and 3-(chloromethyl)benzoyl chloride (6) were stirred with benzyl amine (2a) and cyclohexyl amine (2b), respectively, in aqueous medium at pH 9 – 10 maintained by aqueous sodium carbonate. The resulting benzamides (3a, 3b,7a, 7b) were refluxed with 1-(2-furoyl)piperazine (4) in the presence of K(2)CO(3)and CH3CN to acquire target compounds (5a, 5b,8a, 8b). The spectroscopic techniques including(13)C NMR,H-1 NMR, IR and EI-MS corroborated the proposed molecular structures of final compounds. Among these, two compounds (5b,8b) proved to be considerable inhibitors of butyrylcholinesterase enzyme. Study of the hemolytic activity potential revealed low toxicity level of compound5b.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 300543-56-0. Safety of (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine.
Reference:
Piperazine – Wikipedia,
,Piperazines – an overview | ScienceDirect Topics