1403898-64-5, (2R,5R)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
DIPEA (1.517 mL, 8.68 mmol) was added to 505 7-bromo-4-chloro-6,8-difluoro-3-nitroquinoline (702 mg, 2.17 mmol) and 180 tert-butyl (2R,5R)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (500 mg, 2.17 mmol) in 78 THF (8 mL) at 25 C. The resulting solution was stirred at 80 C. for 4 h. The solvent was removed in vacuo. The crude product was purified by flash silica chromatography (10 to 50% 57 EtOAc in 148 petroleum ether) to afford 732 tert-butyl (2R,5R)-4-(7-bromo-6,8-difluoro-3-nitroquinolin-4-yl)-5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate (861 mg, 77%) as a yellow solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.21 (3H, d), 1.44 (9H, s), 2.84-3.00 (1H, m), 3.27-3.34 (1H, m), 3.47-3.68 (2H, m), 3.70-3.84 (2H, m), 3.97-4.08 (1H, m), 4.21-4.33 (1H, m), 4.64 (1H, t), 7.92 (1H, dd), 9.02 (1H, s); m/z: ES+ [M+H]+=517., 1403898-64-5
As the paragraph descriping shows that 1403898-64-5 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics