109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General Procedure 1. Chemoselective N-acylation reaction of 2-substitued piperazines (6-9, 43-45). 2-Substituted piperazine (6.0 mmol) was dissolved in dry dichloromethane (80 mL) and cooled to 0 oC. A solution of the appropriate acylating agent in dichloromethane (6.0 mmol, 20 mL) was added dropwise in 30 minutes, and then pyridine (9 mmol). The reaction mixture was kept into an ice-water bath with stirring 12 hours and left at room temperature until TLC showed that all the starting material had reacted. The reaction mixture was evaporated to dryness to obtain the corresponding monoacylderivative. Column chromatography gave the pure compounds in high yields. l-tert-Butoxycarbonyl-3-methylpiperazine (6).37 The product was obtained as a syrup and purified by column chromatography using dichloromethane-methanol (15:1) as eluent (0.90 g, 75% yield). MS (CI): m/z 201 (20%) [M+H]+. 1H NMR (500 MHz, DMSO-d6) 0 3.75-3.7 1 (m, 2H), 2.85-2.82 (m, 1H), 2.75-2.69 (m, 1H), 2.60-2.54 (m, 3H), 2.39-2.34 (m, 1H), 1.41 (s, 9H), 0.96 (d, J = 6.3 Hz, 3H). 13C RMN (125 MHz, DMSO-d6) delta 154.5, 79.3, 51.2, 50.5, 45.5, 44.4, 28.6, 19,3. HRMS (m/z): calcd. for C10H20N2O2 200.1528 [M]+.; found 200.1525.
109-07-9, As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.
Reference£º
Patent; SERVICIO ANDALUZ DE SALUD; UNIVERSIDAD DE SEVILLA; SANCHEZ CESPEDES, Javier; PACHON IBANEZ, Maria Eugenia; PACHON DIAZ, Jeronimo; MARTINEZ AGUADO, Pablo; CEBRERO CANGUEIRO, Tania; VEGA PEREZ, Jose Manuel; IGLESIAS GUERRA, Fernando; VEGA HOLM, Margarita; CANDELA LENA, Jose Ignacio; MAZZOTTA, Sarah; (88 pag.)WO2017/144624; (2017); A1;,
Piperazine – Wikipedia
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