With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
mCPBA (<77% pure) (15.6 mg, assumed 0.0693 mmol) in DCM (0.5 mL) was added to a stirred solution of 6- (2 , 6 -dichlorophenyl ) -2- (methylthio) - 8 - (pyridin-3 -yl ) pyrido [4 , 3 -d] pyrimidin-5 ( 6H) -one (25.0 mg, 0.060 mmol) in toluene (2.0 mL) at RT under nitrogen. After 15 min, DIPEA (0.032 mL, 0.181 mmol) and tert-butyl 4-(4- aminophenyl) piperazine-l-carboxylate (16.7 mg, 0.060 mmol) [commercially available] were added, successively, and the temperature was increased to 60 C. After 16 h, the reaction mixture was cooled and loaded directly onto a KP-NH column and purified by flash chromatography (0-100%, EtOAc in cyclohexane) to give the title compound (15.5 mg, 40%) as a yellow solid. LCMS (Method A) : RT = 1.40 min, m/z = 644, 646 [M+H]+. 170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; O’DOWD, Colin Roderick; ROUNTREE, James Samuel Shane; BURKAMP, Frank; WILKINSON, Andrew John; WO2014/167347; (2014); A1;,
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