120737-59-9, tert-Butyl 3-methylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1: tert-Butyl 3-methyl-4- [ (5-nitro-1-benzofuran-7-yl) methyl] piperazine-1- carboxylate A mixture of 7-(bromomethyl)-5-nitro-1-benzofuran (120 mg, 70 mol percent, 0.39 mmol; Intermediate 64), K2C03 (162 mg, 1.17 mmol) and tert-butyl 3-methylpiperazine-1- carboxylate (94 mg, 0.47 mmol) in dry MeCN (5 mL) was heated at 80 ¡ãC while stirring for 1 h 45 min using a StemBlock. The solvent was evaporated under reduced pressure and the residue was partitioned between water and DCM (x2). The organic layers were combined, dried (Na2S04) and purified using flashtube (10percent MeOH in DCM). This afforded the title product (115 mg, 78percent) as a light yellow sticky oil. HPLC 99percent, RT=2. 47 min (System A; 5-60percent MeCN over 3 min), 99percent, RT=2. 27 min (System B; 5-60percent MeCN over 3 min). MS (ESI+) for C19H25N3O5 mlz 376 (M+H) +., 120737-59-9
The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BIOVITRUM AB; WO2005/58858; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics