414910-15-9, tert-Butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
S2: 20L four-neck flask with mechanical stirring and thermometer, nitrogen protection,Add tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (2.40 kg, 9.44 mol),Sodium borohydride (0.71 kg, 18.88 mol), THF 5.06 Kg, cooled to 10 C,Boron trifluoride etherate (2.02 kg, 14.16 mol) was slowly added dropwise, and the temperature was controlled from 0 C to 10 C.After the dropwise addition is completed, the reaction is carried out at 10 C to 25 C for 4 h.The reaction solution was slowly poured into ice water of 5 kg of ice and 5 kg of water, and extracted with methyl tert-butyl ether (4 kg * 2).The methyl tert-butyl ether phase was combined and washed once with 5 kg of saturated sodium chloride solution.Concentration and removal of methyl tert-butyl ether gave a pale-yellow solid, N-Boc-4-(cyclopropylmethyl)piperazine, 2.13 kg, yield 94%.The nuclear magnetic warp alignment is consistent with the standard map.
414910-15-9, 414910-15-9 tert-Butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate 968936, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Suzhou Laikeshide Pharmaceutical Co., Ltd.; Liu Tongchang; Yu Jurong; (6 pag.)CN108341792; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics