With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373608-48-1,tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
1-Benzyl-5-(methylcarbamoyl)-6-oxo- 1,6-dihyd ropyrid ine-3-carboxylic acid (205 mg, 0.716 mmol), HATU (412 mg, 1.084 mmol), DIPEA (0.38 mL, 2.176 mmol), tert-butyl 4-(3- aminopropyl)piperazine-1-carboxylate (344 mg, 1.414 mmol) and DMF (4 mL) were stirred at rt under N2 for 1 h. The solution was concentrated to give 1.18 g of a red oil which was purified bychromatography on 5i02 (Biotage SNAP 25 g cartridge, eluting with O-5O% (2O% (2M ammonia in MeOH) in DCM)/DCM). The appropriate fractions were concentrated to give tert-butyl 4-(3-(1- benzyl-5-(methylcarbamoyl)-6-oxo-1,6-d ihydropyridine-3-carboxamido)propyl)piperazine- 1-carboxylate (497 mg) as a pink solid.LCMS (2 mm Formic): Rt=0.66 mi [MH] = 512., 373608-48-1
373608-48-1 tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate 17750945, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; HOUSE, David; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (141 pag.)WO2017/50714; (2017); A1;,
Piperazine – Wikipedia
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